Catechols: a new class of carbonic anhydrase inhibitors

被引：23
作者：
D'Ambrosio, Katia [1 ]
Carradori, Simone [2 ]
Cesa, Stefania [3 ]
Angeli, Andrea [4 ]
Monti, Simona M. [1 ]
Supuran, Claudiu T. [4 ]
De Simone, Giuseppina [1 ]
机构：
[1] CNR, Ist Biostrutture Bioimmagini, Naples, Italy
[2] G dAnnunzio Univ Chieti Pescara, Dept Pharm, I-66100 Chieti, Italy
[3] Sapienza Univ Rome, Dipartimento Chim & Tecnol Farmaco, I-00185 Rome, Italy
[4] Univ Firenze, Neurofarba Dept, Florence, Italy
来源：
CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 85期
关键词：
GLUTATHIONE-S-TRANSFERASE; ACTIVE-SITE; BINDING; CRYSTALLOGRAPHY; ZINC; BUTYRYLCHOLINESTERASE; ACETYLCHOLINESTERASE; LACTOPEROXIDASE; COUMARINS; MECHANISM;
D O I：
10.1039/d0cc05172a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
To date, catechols have been only poorly investigated as carbonic anhydrase (CA) inhibitors. Here we report the first structural information on the CA inhibition mechanism of these molecules, showing that they adopt a peculiar binding mode to the enzyme active site which involves the zinc-bound water molecule and the "deep water".
引用
收藏
页码：13033 / 13036
页数：4
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