Carcinosarcoma of the prostate - A case report and a possible evidence on the role of hormonal therapy

被引：10

作者：

Sak, SD ^{[1
]}

Orhan, D ^{[1
]}

Yaman, O ^{[1
]}

Tulunay, O ^{[1
]}

Ozdiler, E ^{[1
]}

机构：

[1] ANKARA UNIV,SCH MED,DEPT PATHOL,TR-06100 ANKARA,TURKEY

来源：

UROLOGIA INTERNATIONALIS | 1997年 / 59卷 / 01期

关键词：

prostate; carcinosarcoma; immunohistochemistry; hormonal therapy; progesterone receptor;

D O I：

10.1159/000283018

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

A case of prostatic carcinosarcoma is presented with histopathologic and immunohistochemical characteristics. A 70-year-old man presented with a history of anti-androgen (cyproterone acetate) therapy for prostatic adenocarcinoma, Diffuse and strong staining for progesterone receptor was observed in the carcinosarcoma specimen although it-was completely negative in the previous adenocarcinoma specimen, It may be speculated that hormonal therapy might have facilitated the selection of a progesterone-dependent subclone of tumor cells with the ability of mesenchymal differentiation and that genetic instability due to p53 inactivation might have played a role in this process.

引用

页码：50 / 52

页数：3

共 11 条

[1] IMMUNOHISTOCHEMISTRY AND BIOCHEMISTRY IN DETECTION OF ANDROGEN, PROGESTERONE, AND ESTROGEN-RECEPTORS IN BENIGN AND MALIGNANT HUMAN PROSTATIC TISSUE [J].