Carcinosarcoma of the prostate - A case report and a possible evidence on the role of hormonal therapy

A case of prostatic carcinosarcoma is presented with histopathologic and immunohistochemical characteristics. A 70-year-old man presented with a history of anti-androgen (cyproterone acetate) therapy for prostatic adenocarcinoma, Diffuse and strong staining for progesterone receptor was observed in the carcinosarcoma specimen although it-was completely negative in the previous adenocarcinoma specimen, It may be speculated that hormonal therapy might have facilitated the selection of a progesterone-dependent subclone of tumor cells with the ability of mesenchymal differentiation and that genetic instability due to p53 inactivation might have played a role in this process.