Efficacy and safety of sarilumab in patients with active rheumatoid arthritis

被引：24

作者：

McCarty, Delilah ^{[1
]}

Robinson, April ^{[2
]}

机构：

[1] Novo Nordisk Inc, 800 Scudders Mill Rd, Plainsboro, NJ 08536 USA

[2] Wingate Univ, Sch Pharm, Wingate, NC USA

来源：

THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE | 2018年 / 10卷 / 03期

关键词：

Rheumatoid arthritis; interleukin-6; sarilumab; biologic DMARD; MODIFYING ANTIRHEUMATIC DRUGS; INADEQUATE RESPONSE; METHOTREXATE;

D O I：

10.1177/1759720X17752037

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The mainstay of rheumatoid arthritis (RA) treatment involves the use of medications that slow disease progression and reduce inflammation. Inadequate treatment responses and intolerances to conventional RA treatment have led to the development of biologic agents for the management of moderate-to-severe disease activity. Interleukin-6 (IL-6) inhibition is one of the targets for biologic activity in RA treatment. IL-6 is found in excess in the synovial fluid and contributes to joint erosion through its action on osteoclast cells. Sarilumab is a new IL-6 inhibitor indicated for the treatment of moderate-to-severe RA as monotherapy or in combination with conventional therapies in patients with an inadequate response to previous RA treatment.

引用

页码：61 / 67

页数：7

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