Augmentation of anti-Fas antibody-mediated apoptosis on human glioma cells by liposomes associated with the antibody

被引：10

作者：

Ohta, S

Mizuno, M

Takaoka, T

Yoshida, J

机构：

[1] NAGOYA UNIV,SCH MED,DEPT NEUROSURG,SHOWA KU,NAGOYA,AICHI 466,JAPAN

[2] NATL INST LONGEV SCI,OBU 474,JAPAN

来源：

JOURNAL OF NEURO-ONCOLOGY | 1997年 / 35卷 / 01期

关键词：

apoptosis; glioma; anti-Fas antibody; liposome;

D O I：

10.1023/A:1005843600950

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the susceptibility of five human glioma cell lines to anti-Fas antibody. All human glioma cells tested constitutively expressed Fas antigen on their surfaces and the level of the expression varied slightly in each cell line. The cells had a low susceptibility to anti-Fas antibody-mediated apoptosis. There were four moderately resistant cell lines (U251-SP, U251-MG, SK-MG-1, T98) and one highly resistant cell line (U251 nu/nu). For this study we prepared liposomes containing anti-Fas antibody and studied the augmentation of the antibody-mediated apoptosis. The liposomes induced apoptosis significantly more often than did anti-Fas antibody alone. These results indicate that anti-Fas antibody-mediated apoptosis does not require a critical level of cell surface expression of Fas antigen but rather depends on the intensity of Fas signal transduction.

引用

页码：7 / 11

页数：5

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