Augmentation of anti-Fas antibody-mediated apoptosis on human glioma cells by liposomes associated with the antibody

被引：10
作者：
Ohta, S
Mizuno, M
Takaoka, T
Yoshida, J
机构：
[1] NAGOYA UNIV,SCH MED,DEPT NEUROSURG,SHOWA KU,NAGOYA,AICHI 466,JAPAN
[2] NATL INST LONGEV SCI,OBU 474,JAPAN
来源：
JOURNAL OF NEURO-ONCOLOGY | 1997年 / 35卷 / 01期
关键词：
apoptosis; glioma; anti-Fas antibody; liposome;
D O I：
10.1023/A:1005843600950
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We investigated the susceptibility of five human glioma cell lines to anti-Fas antibody. All human glioma cells tested constitutively expressed Fas antigen on their surfaces and the level of the expression varied slightly in each cell line. The cells had a low susceptibility to anti-Fas antibody-mediated apoptosis. There were four moderately resistant cell lines (U251-SP, U251-MG, SK-MG-1, T98) and one highly resistant cell line (U251 nu/nu). For this study we prepared liposomes containing anti-Fas antibody and studied the augmentation of the antibody-mediated apoptosis. The liposomes induced apoptosis significantly more often than did anti-Fas antibody alone. These results indicate that anti-Fas antibody-mediated apoptosis does not require a critical level of cell surface expression of Fas antigen but rather depends on the intensity of Fas signal transduction.
引用
收藏
页码：7 / 11
页数：5
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