Synthesis of an AIE-active fluorogen and its application in cell imaging

被引：76

作者：

Yu Yong ^{[1
,2
]}

Hong YuNing ^{[1
]}

Feng Chao ^{[3
]}

Liu JianZhao ^{[1
]}

Lam Jacky Wing Yip ^{[1
]}

Faisal Mahtab ^{[1
]}

Ng Ka Ming ^{[2
]}

Luo Kathy Qian ^{[2
,3
]}

Tang Ben Zhong ^{[1
,3
,4
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Chem, Hong Kong, Hong Kong, Peoples R China

[2] HKUST, Dept Chem & Biomol Engn, Kowloon, Hong Kong, Peoples R China

[3] HKUST, Bioengn Grad Program, Kowloon, Hong Kong, Peoples R China

[4] Zhejiang Univ, Inst Biol & Med Macromol, Hangzhou 310027, Peoples R China

来源：

SCIENCE IN CHINA SERIES B-CHEMISTRY | 2009年 / 52卷 / 01期

基金：

中国国家自然科学基金;

关键词：

aggregation-induced emission; biosensor; cell imaging; LIGHT-EMISSION; FLUORESCENT;

D O I：

10.1007/s11426-009-0008-0

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A fluorogen named 1-decyl-1-methyl-2,5-bis{4-[(N,N-diethylamino)methyl]phenyl}-3,4-diphenylsilole (3) was synthesized. It emitted weakly as isolated molecule but strongly as supramolecular aggregate, showing a characteristic behavior of aggregation-induced emission (AIE). The molecules of 3 formed highly emissive nanoparticles in aqueous media, which quickly and selectively marked cytoplasm of HeLa cells and posed no toxicity to the living cells. The fluorogen is thus a promising candidate material for cell imaging as a sensitive, selective and cytocompatible biosensor.

引用

页码：15 / 19

页数：5

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