Synthesis of an AIE-active fluorogen and its application in cell imaging

被引：51
作者：
Yu Yong [1 ,2 ]
Hong YuNing [1 ]
Feng Chao [3 ]
Liu JianZhao [1 ]
Lam Jacky Wing Yip [1 ]
Faisal Mahtab [1 ]
Ng Ka Ming [2 ]
Luo Kathy Qian [2 ,3 ]
Tang Ben Zhong [1 ,3 ,4 ]
机构：
[1] Hong Kong Univ Sci & Technol, Dept Chem, Hong Kong, Hong Kong, Peoples R China
[2] HKUST, Dept Chem & Biomol Engn, Kowloon, Hong Kong, Peoples R China
[3] HKUST, Bioengn Grad Program, Kowloon, Hong Kong, Peoples R China
[4] Zhejiang Univ, Inst Biol & Med Macromol, Hangzhou 310027, Peoples R China
来源：
SCIENCE IN CHINA SERIES B-CHEMISTRY | 2009年 / 52卷 / 01期
基金：
中国国家自然科学基金;
关键词：
aggregation-induced emission; biosensor; cell imaging; LIGHT-EMISSION; FLUORESCENT;
D O I：
10.1007/s11426-009-0008-0
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A fluorogen named 1-decyl-1-methyl-2,5-bis{4-[(N,N-diethylamino)methyl]phenyl}-3,4-diphenylsilole (3) was synthesized. It emitted weakly as isolated molecule but strongly as supramolecular aggregate, showing a characteristic behavior of aggregation-induced emission (AIE). The molecules of 3 formed highly emissive nanoparticles in aqueous media, which quickly and selectively marked cytoplasm of HeLa cells and posed no toxicity to the living cells. The fluorogen is thus a promising candidate material for cell imaging as a sensitive, selective and cytocompatible biosensor.
引用
收藏
页码：15 / 19
页数：5
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