Enhancing endothelial progenitor cell for clinical use

被引：8
作者：
Ye, Lei [1 ]
Poh, Kian-Keong [2 ,3 ]
机构：
[1] Natl Heart Ctr Singapore, Natl Heart Res Inst Singapore, Singapore 169609, Singapore
[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 119077, Singapore
[3] Natl Univ Hlth Syst, Dept Cardiol, Natl Univ Heart Ctr, 1E,Kent Ridge Rd,NUHS Tower Block,Level 9, Singapore 119228, Singapore
来源：
WORLD JOURNAL OF STEM CELLS | 2015年 / 7卷 / 06期
关键词：
Endothelial progenitor cells; Cell therapy; Enhancing function and number; CD34; Clinical trials;
D O I：
10.4252/wjsc.v7.i6.894
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Circulating endothelial progenitor cells (EPCs) have been demonstrated to correlate negatively with vascular endothelial dysfunction and cardiovascular risk factors. However, translation of basic research into the clinical practice has been limited by the lack of unambiguous and consistent definitions of EPCs and reduced EPC cell number and function in subjects requiring them for clinical use. This article critically reviews the definition of EPCs based on commonly used protocols, their value as a biomarker of cardiovascular risk factor in subjects with cardiovascular disease, and strategies to enhance EPCs for treatment of ischemic diseases.
引用
收藏
页码：894 / 898
页数：5
相关论文
共 50 条
[21]   Comparison of endothelial cell- and endothelial progenitor cell-derived exosomes in promoting vascular endothelial cell repair [J].
Hu, Hui ;
Jiang, Chunyu ;
Li, Ruiting ;
Zhao, Jungong .
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2019, 12 (07) :2793-2800
[22]   Prohealing Endothelial Progenitor Cell Capture Stents Do the Cells Captured Explain the Clinical Outcomes? [J].
Leopold, Jane A. .
CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 2013, 6 (05) :494-495
[23]   Endothelial Progenitor Cells and Rheumatoid Arthritis: Response to Endothelial Dysfunction and Clinical Evidences [J].
Komici, Klara ;
Perna, Angelica ;
Rocca, Aldo ;
Bencivenga, Leonardo ;
Rengo, Giuseppe ;
Guerra, Germano .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (24)
[24]   Curcumin reverses diabetes-induced endothelial progenitor cell dysfunction by enhancing MnSOD expression and activity in vitro and in vivo [J].
Kadam, Sheetal ;
Kanitkar, Meghana ;
Dixit, Kadambari ;
Deshpande, Rucha ;
Seshadri, Vasudevan ;
Kale, Vaijayanti .
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2018, 12 (07) :1594-1607
[25]   Sonic hedgehog improves ischemia-induced neovascularization by enhancing endothelial progenitor cell function in type 1 diabetes [J].
Qin, Yuan ;
He, Yan-Huan ;
Hou, Ning ;
Zhang, Gen-Shui ;
Cai, Yi ;
Zhang, Gui-Ping ;
Xiao, Qing ;
He, Li-Shan ;
Li, Su-Juan ;
Yi, Quan ;
Luo, Jian-Dong .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2016, 423 (0C) :30-39
[26]   Long-Term Priming by Three Small Molecules Is a Promising Strategy for Enhancing Late Endothelial Progenitor Cell Bioactivities [J].
Kim, Yeon-Ju ;
Ji, Seung Taek ;
Kim, Da Yeon ;
Jung, Seok Yun ;
Kang, Songhwa ;
Park, Ji Hye ;
Jang, Woong Bi ;
Yun, Jisoo ;
Ha, Jongseong ;
Lee, Dong Hyung ;
Kwon, Sang-Mo .
MOLECULES AND CELLS, 2018, 41 (06) :582-590
[27]   Spotlight on endothelial progenitor cell inhibitors: short review [J].
Thum, T ;
Bauersachs, J .
VASCULAR MEDICINE, 2005, 10 :S59-S64
[28]   Endothelial progenitor cell biology in disease and tissue regeneration [J].
George, Andrea L. ;
Bangalore-Prakash, Pradeep ;
Rajoria, Shilpi ;
Suriano, Robert ;
Shanmugam, Arulkumaran ;
Mittelman, Abraham ;
Tiwari, Raj K. .
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2011, 4
[29]   mTOR inhibition induces endothelial progenitor cell death [J].
Miriuka, S. G. ;
Rao, V. ;
Peterson, M. ;
Tumiati, L. ;
Delgado, D. H. ;
Mohan, R. ;
Ramzy, D. ;
Stewart, D. ;
Ross, H. J. ;
Waddell, T. K. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2006, 6 (09) :2069-2079
[30]   Characterization of Endothelial Progenitor Cell: Past, Present, and Future [J].
Salybekov, Amankeldi A. ;
Kobayashi, Shuzo ;
Asahara, Takayuki .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (14)
12345