Enhancing endothelial progenitor cell for clinical use

被引：8

作者：

Ye, Lei ^{[1
]}

Poh, Kian-Keong ^{[2
,3
]}

机构：

[1] Natl Heart Ctr Singapore, Natl Heart Res Inst Singapore, Singapore 169609, Singapore

[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 119077, Singapore

[3] Natl Univ Hlth Syst, Dept Cardiol, Natl Univ Heart Ctr, 1E,Kent Ridge Rd,NUHS Tower Block,Level 9, Singapore 119228, Singapore

来源：

WORLD JOURNAL OF STEM CELLS | 2015年 / 7卷 / 06期

关键词：

Endothelial progenitor cells; Cell therapy; Enhancing function and number; CD34; Clinical trials;

D O I：

10.4252/wjsc.v7.i6.894

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Circulating endothelial progenitor cells (EPCs) have been demonstrated to correlate negatively with vascular endothelial dysfunction and cardiovascular risk factors. However, translation of basic research into the clinical practice has been limited by the lack of unambiguous and consistent definitions of EPCs and reduced EPC cell number and function in subjects requiring them for clinical use. This article critically reviews the definition of EPCs based on commonly used protocols, their value as a biomarker of cardiovascular risk factor in subjects with cardiovascular disease, and strategies to enhance EPCs for treatment of ischemic diseases.

引用

页码：894 / 898

页数：5

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