Spontaneous Maturation of Neuroblastoma to Ganglioneuroma: Two Case Studies

被引：4

作者：

Yao, Zhi-Gang ^{[1
]}

Liu, Xiu-Mei ^{[2
]}

Qin, Ye-Jun ^{[1
]}

机构：

[1] Shandong Univ, Shandong Prov Hosp, Dept Pathol, Jinan, Peoples R China

[2] Shandong Univ, Qi Lu Childrens Hosp, Dept Pathol, Jinan, Peoples R China

来源：

FETAL AND PEDIATRIC PATHOLOGY | 2016年 / 35卷 / 06期

关键词：

Neuroblastoma; ganglioneuroma; MYCN; TrkA; EXPRESSION; TUMORS; TRKA;

D O I：

10.1080/15513815.2016.1191568

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We describe two children with ganglioneuroma (GN) likely originating from incompletely resected neuroblastoma (NB) during infancy, stages 2A and 2B, who did not undergo postoperative adjuvant chemotherapies. Both NB tumors had no MYCN amplification, had TrKA but no TrkB expression, and by TUNEL had apoptosis. These findings may have contributed to spontaneous maturation of the residual primary NB and hence the favorable prognosis, which suggests surgery alone might be the sufficient initial therapy for low-risk patients.

引用

页码：410 / 415

页数：6

共 18 条

[1] International consensus for neuroblastoma molecular diagnostics: report from the International Neuroblastoma Risk Group (INRG) Biology Committee [J].

Ambros, P. F. ;

Ambros, I. M. ;

Brodeur, G. M. ;

Haber, M. ;

Khan, J. ;

Nakagawara, A. ;

Schleiermacher, G. ;

Speleman, F. ;

Spitz, R. ;

London, W. B. ;

Cohn, S. L. ;

Pearson, A. D. J. ;

Maris, J. M. .

BRITISH JOURNAL OF CANCER, 2009, 100 (09) :1471-1482

[2] MATURATION OF NEUROBLASTOMA TO GANGLIONEUROMA [J].

ATERMAN, K ;

SCHUELLER, EF .

AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1970, 120 (03) :217-+

[3] Clinical prognostic factors in 1277 patients with neuroblastoma: results of The European Neuroblastoma Study Group 'Survey' 1982-1992 [J].

Cotterill, SJ ;

Pearson, ADJ ;

Pritchard, J ;

Foot, ABM ;

Roald, B ;

Kohler, JA ;

Imeson, J .

EUROPEAN JOURNAL OF CANCER, 2000, 36 (07) :901-908

[4] Treatment of localised resectable neuroblastoma. Results of the LNESG1 study by the SIOP Europe Neuroblastoma Group [J].

De Bernardi, B. ;

Mosseri, V. ;

Rubie, H. ;

Castel, V. ;

Foot, A. ;

Ladenstein, R. ;

Laureys, G. ;

Beck-Popovic, M. ;

de Lacerda, A. F. ;

Pearson, A. D. J. ;

De Kraker, J. ;

Ambros, P. F. ;

de Rycke, Y. ;

Conte, M. ;

Bruzzi, P. ;

Michon, J. .

BRITISH JOURNAL OF CANCER, 2008, 99 (07) :1027-1033

[5] MALIGNANT PERIPHERAL-NERVE SHEATH TUMOR ARISING SPONTANEOUSLY FROM RETROPERITONEAL GANGLIONEUROMA - A CASE-REPORT, REVIEW OF THE LITERATURE, AND IMMUNOHISTOCHEMICAL STUDY [J].

GHALI, VS ;

GOLD, JE ;

VINCENT, RA ;

COSGROVE, JM .

HUMAN PATHOLOGY, 1992, 23 (01) :72-75

[6] Neuroblastoma and MYCN [J].

Huang, Miller ;

Weiss, William A. .

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2013, 3 (10)

[7] N-Myc down regulation induced differentiation, early cell cycle exit, and apoptosis in human malignant neuroblastoma cells having wild type or mutant p53 [J].

Janardhanan, Rajiv ;

Banik, Naren L. ;

Ray, Swapan K. .

BIOCHEMICAL PHARMACOLOGY, 2009, 78 (09) :1105-1114

[8] Sporadic synchronous ganglioneuromas in a child-case report and review [J].

Kattepura, Subramanya ;

Alexander, Betty ;

Kini, Usha ;

Das, Kanishka .

JOURNAL OF PEDIATRIC SURGERY, 2010, 45 (04) :822-825

[9] RD3 loss dictates high-risk aggressive neuroblastoma and poor clinical outcomes [J].

Khan, Faizan H. ;

Pandian, Vijayabaskar ;

Ramraj, Satish Kumar ;

Aravindan, Sheeja ;

Natarajan, Mohan ;

Azadi, Seifollah ;

Herman, Terence S. ;

Aravindan, Natarajan .

ONCOTARGET, 2015, 6 (34) :36522-36534

[10] Clinical significance of NTRK family gene expression in neuroblastomas [J].

Light, Jennifer E. ;

Koyama, Hiroshi ;

Minturn, Jane E. ;

Ho, Ruth ;

Simpson, Anisha M. ;

Iyer, Radhika ;

Mangino, Jennifer L. ;

Kolla, Venkatadri ;

London, Wendy B. ;

Brodeur, Garrett M. .

PEDIATRIC BLOOD & CANCER, 2012, 59 (02) :226-232

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