Expression and localization of fibroblast growth factor (FGF)23 and Klotho in the spleen: its physiological and functional implications

被引：14

作者：

Nakashima, Yuri ^{[1
]}

Mima, Toru ^{[1
]}

Yashiro, Mitsuru ^{[1
]}

Sonou, Tomohiro ^{[1
]}

Ohya, Masaki ^{[1
]}

Masumoto, Asuka ^{[1
]}

Yamanaka, Shintaro ^{[1
]}

Koreeda, Daisuke ^{[1
]}

Tatsuta, Koichi ^{[1
]}

Hanba, Yoshiyuki ^{[1
]}

Moribata, Mari ^{[1
]}

Negi, Shigeo ^{[1
]}

Shigematsu, Takashi ^{[1
]}

机构：

[1] Wakayama Med Univ, Dept Nephrol, 811-1 Kimiidera, Wakayama 6418510, Japan

来源：

GROWTH FACTORS | 2016年 / 34卷 / 5-6期

关键词：

FGF23; B cells; Klotho; splenocytes; dendritic cells; VITAMIN-D; DENDRITIC CELLS; MARGINAL ZONE; FGF23; RECEPTOR; MICE; PHOSPHATE;

D O I：

10.1080/08977194.2016.1273222

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The FGF23-Klotho signaling axis is known to exert anti-aging effects via calcium-phosphorus metabolism. In mice deficient in FGF23-Klotho signaling, however, the number of splenocytes is reduced. FGF23 is expressed in both bone and spleen, with regulation of its production differing in these organs. As FGF23-Klotho signaling may play an immunological role in the spleen, splenocytes in male C57BL/6J mice were assayed for expression of Klotho or FGF23 by flow cytometry and immunohistochemistry. Cells that expressed Klotho included CD45R/B220(+) CD21/CD35(+) CD1d(+) CD43(-) marginal zone B cells. These cells also expressed FGF receptor 1, indicating that Klotho-positive B cells could respond to FGF23. Plasmacytoid dendritic cells (pDCs) with CD11c(+) CD45R/B220(+) CD11b(-) CD8(-) were found to produce FGF23. Klotho-positive cells and FGF23-producing cells were present in close proximity to each other, suggesting that FGF23 produced by pDCs may act within a limited area. These findings indicate that FGF23-Klotho signaling could play a biological or immunological role in the spleen.

引用

页码：196 / 202

页数：7

共 29 条

[11] Establishment of the anti-klotho monoclonal antibodies and detection of klotho protein in kidneys [J].

Kato, Y ;

Arakawa, E ;

Kinoshita, S ;

Shirai, A ;

Furuya, A ;

Yamano, K ;

Nakamura, K ;

Iida, A ;

Anazawa, H ;

Koh, N ;

Iwano, A ;

Imura, A ;

Fujimori, T ;

Kuro-o, M ;

Hanai, N ;

Takeshige, K ;

Nabeshima, Y .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 267 (02) :597-602

[12] Mutation of the mouse klotho gene leads to a syndrome resembling ageing [J].

Kuroo, M ;

Matsumura, Y ;

Aizawa, H ;

Kawaguchi, H ;

Suga, T ;

Utsugi, T ;

Ohyama, Y ;

Kurabayashi, M ;

Kaname, T ;

Kume, E ;

Iwasaki, H ;

Iida, A ;

ShirakiIida, T ;

Nishikawa, S ;

Nagai, R ;

Nabeshima, Y .

NATURE, 1997, 390 (6655) :45-51

[13] Regulation of fibroblast growth factor-23 signaling by Klotho [J].

Kurosu, H ;

Ogawa, Y ;

Miyoshi, M ;

Yamamoto, M ;

Nandi, A ;

Rosenblatt, KP ;

Baum, MG ;

Schiavi, S ;

Hu, CM ;

Moe, OW ;

Kuro-o, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (10) :6120-6123

[14] Suppression of aging in mice by the hormone Klotho [J].

Kurosu, H ;

Yamamoto, M ;

Clark, JD ;

Pastor, JV ;

Nandi, A ;

Gurnani, P ;

McGuinness, OP ;

Chikuda, H ;

Yamaguchi, M ;

Kawaguchi, H ;

Shimomura, I ;

Takayama, Y ;

Herz, J ;

Kahn, CR ;

Rosenblatt, KP ;

Kuro-o, M .

SCIENCE, 2005, 309 (5742) :1829-1833

[15] Dendritic cells: Immune regulators in health and disease [J].

Lipscomb, MF ;

Masten, BJ .

PHYSIOLOGICAL REVIEWS, 2002, 82 (01) :97-130

[16] REGULATION AND FUNCTION OF THE FGF23/KLOTHO ENDOCRINE PATHWAYS [J].

Martin, Aline ;

David, Valentin ;

Quarles, L. Darryl .

PHYSIOLOGICAL REVIEWS, 2012, 92 (01) :131-155

[17] Expression of Fgf23 in Activated Dendritic Cells and Macrophages in Response to Immunological Stimuli in Mice [J].

Masuda, Yuki ;

Ohta, Hiroya ;

Morita, Yumiko ;

Nakayama, Yoshiaki ;

Miyake, Ayumi ;

Itoh, Nobuyuki ;

Konishi, Morichika .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2015, 38 (05) :687-693

[18] Structure and function of the spleen [J].

Mebius, RE ;

Kraal, G .

NATURE REVIEWS IMMUNOLOGY, 2005, 5 (08) :606-616

[19] Fate decisions regulating bone marrow and peripheral B lymphocyte development [J].

Monroe, John G. ;

Dorshkind, Kenneth .

ADVANCES IN IMMUNOLOGY, VOL 95, 2007, 95 :1-50

[20] Mouse plasmacytoid cells:: Long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8+ dendritic cells only after microbial stimulus [J].

O'Keeffe, M ;

Hochrein, H ;

Vremec, D ;

Caminschi, I ;

Miller, JL ;

Anders, EM ;

Wu, L ;

Lahoud, H ;

Henri, S ;

Scott, B ;

Hertzog, P ;

Tatarczuch, L ;

Shortman, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (10) :1307-1319

← 1 2 3 →