Tuning the dials of Synthetic Biology

被引：68

作者：

Arpino, James A. J. ^{[1
,2
,3
]}

Hancock, Edward J. ^{[4
]}

Anderson, James ^{[4
,5
]}

Barahona, Mauricio ^{[3
]}

Stan, Guy-Bart V. ^{[1
,6
]}

Papachristodoulou, Antonis ^{[4
]}

Polizzi, Karen ^{[1
,2
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Ctr Synthet Biol & Innovat, London SW7 2AZ, England

[2] Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, London SW7 2AZ, England

[3] Univ London Imperial Coll Sci Technol & Med, Dept Math, London SW7 2AZ, England

[4] Univ Oxford, Dept Engn Sci, Oxford OX1 3PJ, England

[5] St Johns Coll, Oxford OX1 3JP, England

[6] Univ London Imperial Coll Sci Technol & Med, Dept Bioengn, London SW7 2AZ, England

来源：

MICROBIOLOGY-SGM | 2013年 / 159卷

基金：

英国工程与自然科学研究理事会;

关键词：

MESSENGER-RNA STABILITY; ESCHERICHIA-COLI; GENE-EXPRESSION; TRANSLATION INITIATION; COPY NUMBER; LAC REPRESSOR; IN-VIVO; SEQUENCE DETERMINANTS; UNTRANSLATED REGION; REGULATORY NETWORKS;

D O I：

10.1099/mic.0.067975-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Synthetic Biology is the 'Engineering of Biology' - it aims to use a forward-engineering design cycle based on specifications, modelling, analysis, experimental implementation, testing and validation to modify natural or design new, synthetic biology systems so that they behave in a predictable fashion. Motivated by the need for truly plug-and-play synthetic biological components, we present a comprehensive review of ways in which the various parts of a biological system can be modified systematically. In particular, we review the list of 'dials' that are available to the designer and discuss how they can be modelled, tuned and implemented. The dials are categorized according to whether they operate at the global, transcriptional, translational or post-translational level and the resolution that they operate at. We end this review with a discussion on the relative advantages and disadvantages of some dials over others.

引用

页码：1236 / 1253

页数：18

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