Protein kinase C (PKC) family in cancer progression

被引：200
作者：
Koivunen, J
Aaltonen, V
Peltonen, J
机构：
[1] Univ Oulu, Dept Anat & Cell Biol, Oulu 90014, Finland
[2] Univ Oulu, Dept Dermatol, Oulu 90014, Finland
[3] Univ Turku, Dept Anat, FIN-20520 Turku, Finland
来源：
CANCER LETTERS | 2006年 / 235卷 / 01期
基金：
芬兰科学院;
关键词：
cancer; protein kinase C; carcinogenesis;
D O I：
10.1016/j.canlet.2005.03.033
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
PKC family consist of a number of serine-threonine kinases which are divided into three groups based on their activating factors. PKC- have been linked to carcinogenesis since PKC activators can act as tumor promoters. Furthermore, functional studies have suggested that PKCs play a role in the carcinogenesis and maintenance of malipnant phenotype. Potentiation of 0 malignant phenotype may be mediated by activation of selective PKC isoenzymes or through altered isoenzyme expression profile compared to the originating tissue. Activation of PKC alpha and beta isoenzymes have often been linked to malignant phenotype while PKC delta is thought to mediate anti-cancer effects. This review will focus on the regulation and significance of PKC isoenzymes to cancer progression. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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页码：1 / 10
页数：10
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