Genetic visualization of notch signaling in mammalian neurogenesis

被引：48

作者：

Imayoshi, Itaru ^{[1
,2
,3
]}

Shimojo, Hiromi ^{[1
,4
]}

Sakamoto, Masayuki ^{[1
,4
]}

Ohtsuka, Toshiyuki ^{[1
,4
]}

Kageyama, Ryoichiro ^{[1
,4
]}

机构：

[1] Kyoto Univ, Inst Virus Res, Sakyo Ku, Kyoto 6068507, Japan

[2] Kyoto Univ, Hakubi Ctr, Kyoto 6068507, Japan

[3] Japan Sci & Technol Agcy, Precursory Res Embryon Sci & Technol PRESTO, Kyoto 6068507, Japan

[4] Japan Sci & Technol Agcy, CREST, Kyoto 6068507, Japan

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2013年 / 70卷 / 12期

基金：

日本科学技术振兴机构;

关键词：

Notch; NICD; Hes; Hey; Neurogenesis; Adult neurogenesis; Fluorescent reporter; Luciferase reporter; NEURAL STEM-CELLS; OUTER SUBVENTRICULAR ZONE; LOOP-HELIX FACTORS; NERVOUS-SYSTEM; SPATIOTEMPORAL ACTIVATION; OSCILLATORY EXPRESSION; ULTRADIAN OSCILLATIONS; ADULT NEUROGENESIS; NEURONS ARISE; RADIAL GLIA;

D O I：

10.1007/s00018-012-1151-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Notch signaling plays crucial roles in fate determination and the differentiation of neural stem cells in embryonic and adult brains. It is now clear that the notch pathway is under more complex and dynamic regulation than previously thought. To understand the functional details of notch signaling more precisely, it is important to reveal when, where, and how notch signaling is dynamically communicated between cells, for which the visualization of notch signaling is essential. In this review, we introduce recent technical advances in the visualization of notch signaling during neural development and in the adult brain, and we discuss the physiological significance of dynamic regulation of notch signaling.

引用

页码：2045 / 2057

页数：13

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