Melatonin-Based Therapeutics for Neuroprotection in Stroke

被引:21
作者
Shinozuka, Kazutaka [1 ]
Staples, Meaghan [1 ]
Borlongan, Cesar V. [1 ]
机构
[1] Univ S Florida, Ctr Excellence Aging & Brain Repair, Dept Neurosurg & Brain Repair, Coll Med, Tampa, FL 33612 USA
来源
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 05期
关键词
oxidative stress; stroke; neuroprotection; cerebral ischemia; melatonin; FOCAL CEREBRAL-ISCHEMIA; NEURAL STEM-CELLS; CENTRAL-NERVOUS-SYSTEM; SPONTANEOUSLY HYPERTENSIVE-RATS; NITRIC-OXIDE SYNTHASE; MIDBRAIN DOPAMINERGIC-NEURONS; TRANSIENT FOREBRAIN ISCHEMIA; AMNIOTIC EPITHELIAL-CELLS; ARTERY OCCLUSION; PARKINSONS-DISEASE;
D O I
10.3390/ijms14058924
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The present review paper supports the approach to deliver melatonin and to target melatonin receptors for neuroprotection in stroke. We discuss laboratory evidence demonstrating neuroprotective effects of exogenous melatonin treatment and transplantation of melatonin-secreting cells in stroke. In addition, we describe a novel mechanism of action underlying the therapeutic benefits of stem cell therapy in stroke, implicating the role of melatonin receptors. As we envision the clinical entry of melatonin-based therapeutics, we discuss translational experiments that warrant consideration to reveal an optimal melatonin treatment strategy that is safe and effective for human application.
引用
收藏
页码:8924 / 8947
页数:24
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