Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications

被引:834
作者
Dadfar, Seyed Mohammadali [1 ]
Roemhild, Karolin [1 ,2 ]
Drude, Natascha I. [1 ,3 ,4 ]
von Stillfried, Saskia [2 ]
Knuechel, Ruth [2 ]
Kiessling, Fabian [1 ]
Lammers, Twan [1 ,5 ,6 ]
机构
[1] RWTH Aachen Univ Clin, Inst Expt Mol Imaging, Dept Nanomed & Theranost, Aachen, Germany
[2] RWTH Aachen Univ Clin, Med Fac, Inst Pathol, Aachen, Germany
[3] RWTH Aachen Univ Clin, Dept Nucl Med, Aachen, Germany
[4] Rhein Westfal TH Aachen, Leibniz Inst Interact Mat DWI, Aachen, Germany
[5] Univ Utrecht, Dept Pharmaceut, Utrecht, Netherlands
[6] Univ Twente, Dept Targeted Therapeut, Enschede, Netherlands
基金
欧洲研究理事会;
关键词
SPION; USPIO; MRI; MPI; MEN; Nanomedicine; Theranostics; ULTRASMALL SUPERPARAMAGNETIC PARTICLES; COATED MAGNETITE NANOPARTICLES; INTRAVASCULAR CONTRAST AGENT; LYMPH-NODE METASTASES; IN-VIVO; MR-ANGIOGRAPHY; POLYETHYLENE-GLYCOL; SURFACE MODIFICATION; POLYMERIC MICELLES; PROSTATE-CANCER;
D O I
10.1016/j.addr.2019.01.005
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Many different iron oxide nanoparticles have been evaluated over the years, for a wide variety of biomedical applications. We here summarize the synthesis, surface functionalization and characterization of iron oxide nanoparticles, as well as their (pre-) clinical use in diagnostic, therapeutic and theranostic settings. Diagnostic applications include liver, lymph node, inflammation and vascular imaging, employing mostly magnetic resonance imaging but recently also magnetic particle imaging. Therapeutic applications encompass iron supplementation in anemia and advanced cancer treatments, such as modulation of macrophage polarization, magnetic fluid hyperthermia and magnetic drug targeting. Because of their properties, iron oxide nanoparticles are particularly useful for theranostic purposes. Examples of such setups, in which diagnosis and therapy are intimately combined and in which iron oxide nanoparticles are used, are image-guided drug delivery, image-guided and microbubble-mediated opening of the blood-brain barrier, and theranostic tissue engineering. Together, these directions highlight the versatility and the broad applicability of iron oxide nanoparticles, and indicate the integration in future medical practice of multiple iron oxide nanoparticle-based materials. (C) 2019 Elsevier B.V. All rights reserved.
引用
收藏
页码:302 / 325
页数:24
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