Direct Access to 1,3,5-Trisubstituted 1H-1,2,4-Triazoles from N-Phenylbenzamidines via Copper-Catalyzed Diamination of Aryl Nitriles

被引：10

作者：

Zhang, Lutao ^{[1
]}

Tang, Dong ^{[1
]}

Gao, Jing ^{[1
]}

Wang, Jing ^{[1
]}

Wu, Ping ^{[1
]}

Meng, Xu ^{[2
]}

Chen, Baohua ^{[1
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2016年 / 48卷 / 22期

基金：

中国国家自然科学基金;

关键词：

amination; copper; heterocycles; ring closure; tandem reaction; ONE-POT SYNTHESIS; BOND FORMATION; 1,2,4-TRIAZOLES; AMIDINES; CYCLOADDITION; DERIVATIVES; IMIDAZOLES; ARYLATION; CHLORIDES;

D O I：

10.1055/s-0035-1562490

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed formation of C-N/N-N bonds using N-phenylbenzamidines with aryl nitriles has been developed and affords a route to 1,3,5-trisubstituted 1H-1,2,4-triazoles in moderate to excellent yields. The method is operationally simple and environmentally benign with a large substrate scope available and represents an economical path for numerous C-N/N-N bond formations.

引用

页码：3924 / 3930

页数：7

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