Hydrogen peroxide-induced MAPK activation causes the increase of RCAN1 (DSCR1) protein expression

被引：0
作者：
Kim, Seon Sook [1 ]
Seo, Su Ryeon [1 ]
机构：
[1] Kangwon Natl Univ, Dept Mol Biosci, Coll Biomed Sci, Inst Biosci & Biotechnol, Chunchon 200701, South Korea
来源：
GENES & GENOMICS | 2013年 / 35卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
RCAN1/DSCR1/ADAPT78; Hydrogen peroxide; MAPKs; ROS; DOWN-SYNDROME; CELL-DEATH; OXIDATIVE STRESS; ALZHEIMERS-DISEASE; SIGNALING PATHWAYS; CALCINEURIN; ADAPT78; KINASE; GENE; OVEREXPRESSION;
D O I：
10.1007/s13258-013-0080-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Down syndrome critical region 1 (DSCR1) gene encodes a regulator of calcineurin 1 (RCAN1), which is overexpressed in the patients with Down syndrome. In this study, we found that the protein expression of RCAN1 was increased by the hydrogen peroxide (H2O2). The increase of RCAN1 expression by H2O2 was blocked by the treatment with anti-oxidants and inhibitors of mitogen-activated protein kinases (MAPKs), indicating that this increase was caused by the generation of reactive oxygen species and activation of MAPKs. In addition, we found that the phosphorylation of RCAN1 by H2O2 caused an increase of RCAN1 expression by increasing of the half-life of the protein. Our results provide the evidence that H2O2 acts as an important regulator in the control of RCAN1 protein expression through phosphorylation.
引用
收藏
页码：111 / 116
页数：6
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