Sex hormone levels in the serum of patients with pancreatic adenocarcinoma

被引:24
作者
Fyssas, I
Syrigos, KN
Konstandoulakis, MM
Papadopoulos, S
Milingos, N
Anapliotou, M
Waxman, J
Golematis, BC
机构
[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT CLIN ONCOL,LONDON W12 0HS,ENGLAND
[2] HIPPOKRATIO GEN HOSP,ATHENS MED SCH,DEPT PROPAEDEUT SURG 1,ATHENS,GREECE
[3] LAIKON GEN HOSP,ATHENS MED SCH,DEPT PATHOPHYSIOL,ENDOCRINE UNIT,ATHENS,GREECE
关键词
luteinising hormone; follicle stimulating hormone; oestradiol; progesterone; testosterone; D4-androstenedione; pancreatic cancer;
D O I
10.1055/s-2007-979002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The objective of this study was to evaluate the levels of several pituitary and gonadal hormones in pancreatic adenocarcinoma. We examined circulating levels of LH, FSH, Testosterone, Oestradiol, Progesterone and Delta 4-Androstenedione in 36 patients with pancreatic adenocarcinoma, 12 patients with chronic pancreatitis and 87 age matched controls. According to our findings males with pancreatic cancer were found to have higher levels of FSH (p<0.01), LH and oestradiol (p<0.001) and lower levels of progesterone (p<0.01) and testosterone (p<0.05) than the controls. Female patients with pancreatic cancer were found to have higher levels of oestradiol (p<0.001) and lower levels of LH, FSH and progesterone (p<0.001), compared with group of healthy volunteers. Our data provide evidence of a generalised dysfunction of the hypothalamic-hypophysial-gonadal axis in pancreatic cancer patients.
引用
收藏
页码:115 / 118
页数:4
相关论文
共 27 条