Nicotine and pathological angiogenesis

被引:100
|
作者
Lee, Jieun [1 ]
Cooke, John P. [1 ]
机构
[1] Stanford Univ, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA
关键词
Nicotine; Atherosclerosis; Angiogenesis; nAChR (nicotinic acetylcholine receptor); Choroidal neovascularization; ENDOTHELIAL PROGENITOR CELLS; ACETYLCHOLINE-RECEPTOR; GROWTH-FACTOR; DNA-SYNTHESIS; VASA VASORUM; LUNG-CANCER; EXPRESSION; NEOVASCULARIZATION; CHOLINE; EXPOSURE;
D O I
10.1016/j.lfs.2012.06.032
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
This paper describes the role of endothelial nicotinic acetylcholine receptors (nAChR) in diseases where pathological angiogenesis plays a role. An extensive review of the literature was performed, focusing on studies that investigated the effect of nicotine upon angiogenesis. Nicotine induces pathological angiogenesis at clinically relevant concentrations (i.e. at tissue and plasma concentrations similar to those of a light to moderate smoker). Nicotine promotes endothelial cell migration, proliferation, survival, tube formation and nitric oxide (NO) production in vitro, mimicking the effect of other angiogenic growth factors. These in vitro findings indicate that there may be an angiogenic component to the pathophysiology of major tobacco related diseases such as carcinoma, atherosclerosis, and age-related macular degeneration. Indeed, nicotine stimulates pathological angiogenesis in pre-clinical models of these disorders. Subsequently, it has been demonstrated that nicotine stimulates nAChRs on the endothelium to induce angiogenic processes, that these nAChRs are largely of the alpha 7 homomeric type, and that there are synergistic interactions between the nAChRs and angiogenic growth factor receptors at the phosphoproteomic and genomic levels. These findings are of potential clinical relevance, and provide mechanistic insights into tobacco-related disease. Furthermore, these findings may lead to novel therapies for diseases characterized by insufficient or inappropriate angiogenesis. (C) 2012 Published by Elsevier Inc.
引用
收藏
页码:1058 / 1064
页数:7
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