Novel 1,2,3,4-Tetrahydroquinazolinones via Reaction of 2-Amino-N-substituted Benzamides and Dimethyl Acetylenedicarboxylate

被引：13

作者：

Nahavandian, Semiramis ^{[1
]}

Allameh, Sadegh ^{[1
]}

Saeedi, Mina ^{[2
,3
]}

Ansari, Shirin ^{[4
,5
]}

Mahdavi, Mohammad ^{[4
,5
]}

Foroumadi, Alireza ^{[4
,5
]}

Shafiee, Abbas ^{[4
,5
]}

机构：

[1] Islamic Azad Univ, Mashhad Branch, Dept Chem, Mashhad, Iran

[2] Univ Tehran Med Sci, Med Plants Res Ctr, Fac Pharm, Tehran, Iran

[3] Univ Tehran Med Sci, Persian Med & Pharm Res Ctr, Tehran, Iran

[4] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, Tehran, Iran

[5] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Tehran, Iran

来源：

HELVETICA CHIMICA ACTA | 2015年 / 98卷 / 07期

基金：

美国国家科学基金会;

关键词：

Quinazolinones; Benzamides; Acetylenedicarboxylate; dimethyl (DMAD); Water-mediated reaction; DERIVATIVES; WATER; QUINAZOLINE; INHIBITORS; EFFICIENT;

D O I：

10.1002/hlca.201500015

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reaction of 2-amino-N-substituted benzamides and dimethyl acetylenedicarboxylate (DMAD) in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in H2O at room temperature led to the formation of novel 1,2,3,4-tetrahydroquinazolinones.

引用

页码：1028 / 1033

页数：6

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