Kavalactone Metabolism in the Isolated Perfused Rat Liver

被引：3
|
作者：
Fu, Shuang [1 ]
Rowe, Anthony [1 ]
Ramzan, Iqbal [1 ]
机构：
[1] Univ Sydney, Fac Pharm, Sydney, NSW 2006, Australia
来源：
PHYTOTHERAPY RESEARCH | 2012年 / 26卷 / 12期
关键词：
biliary excretion; hepatic clearance; kavalactone; liver; metabolism; pharmacokinetics; URINARY METABOLITES; DISPOSITION;
D O I：
10.1002/ptr.4656
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Metabolic pathways for kavalactone metabolism in humans and rats have been identified, but more detailed description of the enzyme kinetics involved is lacking. The disposition profiles of three of the six major kavalactones (kavain, methysticin and desmethoxyyangonin) and their respective metabolites (p-hydroxykavain, m,p-dihydroxykavain and p-hydroxy-5,6-dehydrokavain) were examined in the perfusate and bile of the isolated perfused rat liver. The metabolism of the kavalactones is first-order in nature with similar decay half-lives. p-Hydroxykavain and m,p-dihydroxykavain were the only metabolites detected in the perfusate. Kavalactone biliary excretion was negligible. Copyright (c) 2012 John Wiley & Sons, Ltd.
引用
收藏
页码：1813 / 1816
页数：4
相关论文
共 50 条
  • [1] Kavalactone Metabolism in Rat Liver Microsomes
    Fu, Shuang
    Rowe, Anthony
    Ramzan, Iqbal
    PHYTOTHERAPY RESEARCH, 2012, 26 (07) : 1057 - 1061
  • [2] Macrophage depletion ameliorates kavalactone damage in the isolated perfused rat liver
    Zhang, Lillian
    Rowe, Anthony
    Braet, Filip
    Ramzan, Iqbal
    JOURNAL OF TOXICOLOGICAL SCIENCES, 2012, 37 (02): : 447 - 453
  • [3] Metabolism of flupyrazofos in the isolated perfused rat liver
    Jeong, CK
    Lee, HY
    Kim, SB
    Choi, SJ
    Kim, JH
    Kim, K
    Han, SS
    Lee, HS
    PEST MANAGEMENT SCIENCE, 2001, 57 (05) : 427 - 431
  • [4] Inhibition of mirtazapine metabolism by Ecstasy (MDMA) in isolated perfused rat liver model
    Jamshidfar, Sanaz
    Ardakani, Yalda H.
    Lavasani, Hoda
    Rouini, Mohammadreza
    DARU-JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 25
  • [5] Poloxamer 407 Increases the Recovery of Paracetamol in the Isolated Perfused Rat Liver
    Mitchell, Sarah J.
    Huizer-Pajkos, Aniko
    Cogger, Victoria C.
    Mclachlan, Andrew J.
    Le Couteur, David G.
    Hilmer, Sarah N.
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2011, 100 (01) : 334 - 340
  • [6] METABOLISM OF GARLIC CONSTITUENTS IN THE ISOLATED PERFUSED-RAT-LIVER
    EGENSCHWIND, C
    ECKARD, R
    KEMPER, FH
    PLANTA MEDICA, 1992, 58 (04) : 301 - 305
  • [7] THE METABOLISM OF RECOMBINANT ERYTHROPOIETIN IN THE ISOLATED PERFUSED-RAT-LIVER
    NIELSEN, OJ
    EGFJORD, M
    HIRTH, P
    LIVER, 1990, 10 (06): : 343 - 349
  • [8] Inhibition of mirtazapine metabolism by Ecstasy (MDMA) in isolated perfused rat liver model
    Sanaz Jamshidfar
    Yalda H. Ardakani
    Hoda Lavasani
    Mohammadreza Rouini
    DARU Journal of Pharmaceutical Sciences, 25
  • [9] Metabolism of camptothecin, a potent topoisomerase I inhibitor, in the isolated perfused rat liver
    Peter Platzer
    Theresia Thalhammer
    Gerhard Hamilton
    Ernst Ulsperger
    Erwin Rosenberg
    Rene Wissiack
    Walter Jäger
    Cancer Chemotherapy and Pharmacology, 2000, 45 : 50 - 54
  • [10] Metabolism of the new ribonucleotide reductase inhibitor amidox in the isolated perfused rat liver
    Salamon, A
    Vielnascher, E
    Hagenauer, B
    Szekeres, T
    Szekeres-Fritzer, M
    Thalhammer, T
    Jäger, W
    ANTICANCER RESEARCH, 2000, 20 (5B) : 3521 - 3526
12345