Multivariate Analysis of Molecular Indicators for Postoperative Liver Metastasis in Colorectal Cancer Cases

被引:8
作者
Qian, Li-Yuan [1 ]
Li, Ping [2 ]
Li, Xiao-Rong [1 ]
Chen, Dao-Jin [1 ]
Zhu, Shai-Hong [1 ]
机构
[1] Cent S Univ, Dept Gen Surg, Xiangya Hosp 3, Changsha, Hunan, Peoples R China
[2] Cent S Univ, Dept Burn & Plast Surg, Xiangya Hosp 3, Changsha, Hunan, Peoples R China
关键词
Colorectal cancer; post-operative liver metastasis; molecular indicators; multivariate analysis; GROWTH-FACTOR RECEPTOR; CARCINOEMBRYONIC ANTIGEN; PROGNOSTIC-SIGNIFICANCE; NM23-H1; EXPRESSION; COLON-CANCER; VEGF; THERAPY; MATRIX; GENE; METALLOPROTEINASES;
D O I
10.7314/APJCP.2012.13.8.3967
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Aims: To explore the relationship between various molecular makers and liver metastasis of colorectal cancer (CRC). Method: Using immunohistochemistry, protein expression of CEA, nm23, c-met, MMP2, COX-2, VEGF, EGFR, and CD44 was assessed in 80 CRC cases. The Chi-square test and logistic regression were performed to analyze the relationship between these indicators and CRC liver metastasis. Results: There were significant differences in expression of CEA, MMP2, CD44, VEGF and EGFR between the liver metastasis and non metastasis groups (P < 0.05); no significant differences were noted for nm23, c-met, and COX-2 expression. Logistic regression analysis showed that only CEA, VEGF, and EGFR entered into the regression equation, and had significant correlations with CRC liver metastasis (alpha inclusion=0.10, alpha elimination = 0.15, R2 = 0.718). Conclusions: Combination detection of CEA, VEGF, and EGFR may be an effective means to predict CRC liver metastasis. Nm23, c-met, MMP2, COX-2, and CD44, in contrast, are not suitable as prognostic markers.
引用
收藏
页码:3967 / 3971
页数:5
相关论文
共 32 条
[1]   CD44 IS THE PRINCIPAL CELL-SURFACE RECEPTOR FOR HYALURONATE [J].
ARUFFO, A ;
STAMENKOVIC, I ;
MELNICK, M ;
UNDERHILL, CB ;
SEED, B .
CELL, 1990, 61 (07) :1303-1313
[2]   Is carcino-embryonic antigen useful in the follow-up management of patients with colorectal liver metastases? [J].
Bakalakos, EA ;
Burak, WE ;
Young, DC ;
Martin, EW .
AMERICAN JOURNAL OF SURGERY, 1999, 177 (01) :2-6
[3]   Surgical therapy for metastatic disease to the liver [J].
Bentrem, DJ ;
DeMatteo, RP ;
Blumgart, LH .
ANNUAL REVIEW OF MEDICINE, 2005, 56 :139-156
[4]   Biology of colorectal liver metastases: A review [J].
Bird, Nigel C. ;
Mangnall, David ;
Majeed, Ali W. .
JOURNAL OF SURGICAL ONCOLOGY, 2006, 94 (01) :68-80
[5]   Expression of HIF-1alpha and VEGF in colorectal cancer: association with clinical outcomes and prognostic implications [J].
Cao, Dan ;
Hou, Mei ;
Guan, Yong-song ;
Jiang, Ming ;
Yang, Yu ;
Gou, Hong-feng .
BMC CANCER, 2009, 9
[6]   Gene therapy strategies for colon cancer [J].
Chung-Faye, GA ;
Kerr, DJ ;
Young, LS ;
Searle, PF .
MOLECULAR MEDICINE TODAY, 2000, 6 (02) :82-87
[7]   Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer [J].
Cox, DG ;
Pontes, C ;
Guino, E ;
Navarro, M ;
Osorio, A ;
Canzian, F ;
Moreno, V .
BRITISH JOURNAL OF CANCER, 2004, 91 (02) :339-343
[8]  
DIRENZO MF, 1995, CLIN CANCER RES, V1, P147
[9]   Matrix metalloproteinase 2 promotes cell growth and invasion in colorectal cancer [J].
Dong, Wei ;
Li, Hong ;
Zhang, Yan ;
Yang, Heng ;
Guo, Min ;
Li, Li ;
Liu, Tongjun .
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2011, 43 (11) :840-848
[10]   Prognostic implication of nm23-H1 expression in colorectal carcinomas [J].
Dursun, A ;
Akyürek, N ;
Günel, N ;
Yamaç, D .
PATHOLOGY, 2002, 34 (05) :427-432