Stimuli-responsive polymer-based systems for diagnostic applications

被引：43
|
作者：
Shu, Tong [1 ]
Hu, Liang [2 ,3 ]
Shen, Qiming [4 ]
Jiang, Li [2 ,3 ]
Zhang, Qiang [5 ]
Serpe, Michael J. [4 ]
机构：
[1] Shenzhen Univ, Sch Biomed Engn, Hlth Sci Ctr, Shenzhen 518060, Guangdong, Peoples R China
[2] Soochow Univ, State Key Lab Radiat Med & Protect, Sch Radiol & Interdisciplinary Sci RAD X, 199 Renai Rd, Suzhou 215123, Peoples R China
[3] Soochow Univ, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst, 199 Renai Rd, Suzhou 215123, Peoples R China
[4] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada
[5] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, 5625 Renmin St, Changchun 130022, Peoples R China
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2020年 / 8卷 / 32期
基金：
中国国家自然科学基金; 加拿大创新基金会; 加拿大自然科学与工程研究理事会;
关键词：
TUMOR-NECROSIS-FACTOR; MICROGEL-BASED ETALONS; N-ISOPROPYLACRYLAMIDE; BIOMEDICAL APPLICATIONS; CONJUGATED POLYMER; THERMOSENSITIVE LIPOSOME; PHASE-TRANSITION; RECENT PROGRESS; FLUORESCENT; DNA;
D O I：
10.1039/d0tb00570c
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Stimuli-responsive polymers exhibit properties that make them ideal candidates for biosensing and molecular diagnostics. Through rational design of polymer composition combined with new polymer functionalization and synthetic strategies, polymers with myriad responsivities,e.g., responses to temperature, pH, biomolecules, CO2, light, and electricity can be achieved. When these polymers are specifically designed to respond to biomarkers, stimuli-responsive devices/probes, capable of recognizing and transducing analyte signals, can be used to diagnose and treat disease. In this review, we highlight recent state-of-the-art examples of stimuli-responsive polymer-based systems for biosensing and bioimaging.
引用
收藏
页码：7042 / 7061
页数：20
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