Neuropathic pain: aetiology, symptoms, mechanisms, and management

被引：1571

作者：

Woolf, CJ ^{[1
]}

Mannion, RJ

机构：

[1] Massachusetts Gen Hosp, Dept Anesthesia & Crit Care, Neural Plast Res Grp, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Charlestown, MA 02129 USA

来源：

LANCET | 1999年 / 353卷 / 9168期

关键词：

D O I：

10.1016/S0140-6736(99)01307-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We highlight current theories about peripheral neuropathic pain and show that progress in management is contingent on targeting treatment not at the aetiological factors or the symptoms but at the mechanisms that operate to produce the symptoms. This approach will require substantial progress in our understanding of the pathophysiology of neuropathic pain, the development of accurate diagnostic tools to discover what mechanisms contribute to the pain syndrome in an individual, and effective treatments aimed specifically at the mechanisms.

引用

页码：1959 / 1964

页数：6

共 35 条

[1] POSTHERPETIC NEURALGIA - ARE C-NOCICEPTORS INVOLVED IN SIGNALING AND MAINTENANCE OF TACTILE ALLODYNIA [J].