Syntheses, Characterizations and Antitumor Activities of Two Copper(II) Complexes with an Acylhydrazone Ligand Bearing Pyrrole Unit

被引:11
作者
Han Xue-Feng [1 ]
Cai Hong-Xin [2 ]
Jia Lei [2 ]
Wu Wei-Na [2 ]
Zhang Xin [3 ]
Xu Jun [2 ]
Zhang Zhao-Po [2 ]
Wang Yuan [2 ]
机构
[1] Henan Polytech Univ, Dept Personnel, Jiaozuo 454000, Henan, Peoples R China
[2] Henan Polytech Univ, Dept Chem & Phys, Jiaozuo 454000, Henan, Peoples R China
[3] China Agr Univ, Coll Agr & Biotechnol, Beijing 100083, Peoples R China
关键词
acylhydrazone; Cu(II) complex; pyrrole; antitumor activity; CU(II) COMPLEXES; ANTIOXIDANT ACTIVITIES; BIOLOGICAL-ACTIVITIES; CRYSTAL-STRUCTURES; 2-ACETYLPYRIDINE; HYDRAZONE; BINDING; NI(II);
D O I
10.11862/CJIC.2015.188
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Two interesting copper(1) complexes,[Cu(H2L)(2)(THF)] (1) and[Cu-2(L)Cl(CH3OH)]center dot H2O (2) based on H3L {ethyl 5-[(2-hydroxy1-4-methylbenzoyDamino-iminomethyl]-3,4-dimethyl-pyrrole-2-carboxylate} were synthesized and characterized by X-ray diffraction analyses. The results show that in complex 1, the copper (11) ion is surrounded by two mono-deprotonated acylhydrazone ligands with NO donor sets and one THF molecule, and thus possesses a distorted square pyramidal geometry. However, in binuclear complex 2, the acylhydrazone ligand is tri-d.eprotonated and bridges two copper(II) ions with square-planar coordination geometry through NO and N2O2 atom sets, respectively. Both complexes have excellent antitumor activities towards A549, ECA109 and SGC7901 cancer cells. CCDC: 1040334, H3L center dot H2O center dot CH3CH2OH; 1040335, 1; 1040336, 2.
引用
收藏
页码:1453 / 1459
页数:7
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