Synthesis and biological activities of a novel class of azole-containing antifungal agents

被引：13

作者：

Liu, LT

Lin, YC

Wang, CLJ

Lin, MS

Yen, SC

Chen, HJ

机构：

[1] Development Center for Biotechnology, Shih-Chih, Taipei, 102, Lane 169, Kang-Ning St.

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 12期

关键词：

D O I：

10.1016/0960-894X(96)00222-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel 1,2,3,4-tetrahydroisoquinoline derived azoles has been designed and synthesized as antifungal agents which might function as inhibitors of cytochrome P-450 dependent lanosterol 14 alpha-demethylase. In vitro tests showed that some of these compounds, especially 5b and 6b, effectively inhibit the growth of several strains of yeasts as well as molds. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1335 / 1338

页数：4

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