Pten Deletion Promotes Regrowth of Corticospinal Tract Axons 1 Year after Spinal Cord Injury

被引：124

作者：

Du, Kaimeng ^{[1
,2
,3
]}

Zheng, Susu ^{[1
,2
,3
]}

Zhang, Qian ^{[1
,2
,3
]}

Li, Songshan ^{[1
,2
,3
]}

Gao, Xin ^{[1
,2
,3
]}

Wang, Juan ^{[4
,5
]}

Jiang, Liwen ^{[4
,5
]}

Liu, Kai ^{[1
,2
,3
]}

机构：

[1] Hong Kong Univ Sci & Technol, Div Life Sci, State Key Lab Mol Neurosci, Kowloon, Hong Kong, Peoples R China

[2] Hong Kong Univ Sci & Technol, Sch Sci, Ctr Syst Biol & Human Hlth, Kowloon, Hong Kong, Peoples R China

[3] Hong Kong Univ Sci & Technol, Inst Adv Study, Kowloon, Hong Kong, Peoples R China

[4] Chinese Univ Hong Kong, Sch Life Sci, Ctr Cell & Dev Biol, Shatin, Hong Kong, Peoples R China

[5] Chinese Univ Hong Kong, State Key Lab Agrobiotechnol, Shatin, Hong Kong, Peoples R China

来源：

JOURNAL OF NEUROSCIENCE | 2015年 / 35卷 / 26期

关键词：

axon regeneration; axon sprouting; chronic spinal cord injury; corticospinal tract; intrinsic axon growth ability; Pten; REGENERATIVE GROWTH; ADULT; NEURONS; MECHANISMS; RECOVERY; AXOTOMY; CELLS; CNS;

D O I：

10.1523/JNEUROSCI.3637-14.2015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Chronic spinal cord injury (SCI) is a formidable hurdle that prevents a large number of injured axons from crossing the lesion, particularly the corticospinal tract (CST). This study shows that Pten deletion in the adult mouse cortex enhances compensatory sprouting of uninjured CST axons. Furthermore, forced upregulation of mammalian target of rapamycin (mTOR) initiated either 1 month or 1 year after injury promoted regeneration of CST axons. Our results indicate that both developmental and injury-induced mTOR downregulation in corticospinal motor neurons can be reversed in adults. Modulating neuronal mTOR activity is a potential strategy for axon regeneration after chronic SCI.

引用

页码：9754 / 9763

页数：10

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