E-cadherin acts as a positive regulator of the JAK-STAT signaling pathway during Drosophila oogenesis

被引:3
|
作者
Mallart, Charlotte [1 ]
Chalvet, Fabienne [1 ]
Netter, Sophie [2 ]
Torres, Alba Yurani [1 ,3 ]
Poidevin, Mickael [1 ]
Montagne, Jacques [1 ]
Pret, Anne-Marie [2 ]
Malartre, Marianne [1 ]
机构
[1] Univ Paris Saclay, Inst Integrat Biol Cell I2BC, CEA, CNRS, Gif Sur Yvette, France
[2] Univ Paris Saclay, Inst Integrat Biol Cell I2BC, UVSQ, CEA,CNRS, Gif Sur Yvette, France
[3] Univ Calif Santa Barbara, Mol Cellular & Dev Biol Dept, Santa Barbara, CA USA
来源
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 10卷
关键词
JAK-STAT; signaling; oogenesis; E-cadherin; morphogenesis; apoptosis; BORDER CELL-MIGRATION; JAK/STAT PATHWAY; DE-CADHERIN; FEEDBACK INHIBITION; ADHESION; DIFFERENTIATION; LOCALIZATION; ACTIVATION; AXIS;
D O I
10.3389/fcell.2022.886312
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The JAK-STAT pathway is evolutionary conserved. The simplicity of this signaling in Drosophila, due to the limited redundancy between pathway components, makes it an ideal model for investigation. In the Drosophila follicular epithelium, highly stereotyped functions of JAK-STAT signaling have been well characterized, but how signaling activity is regulated precisely to allow the different outcomes is not well understood. In this tissue, the ligand is secreted by the polar cells positioned at each follicle extremity, thus generating a gradient of JAK-STAT activity in adjacent cells. One way to control the delivered quantity of ligand is by regulating the number of polar cells, which is reduced by apoptosis to exactly two at each pole by mid-oogenesis. Hence, JAK-STAT activity is described as symmetrical between follicle anterior and posterior regions. Here, we show that JAK-STAT signaling activity is actually highly dynamic, resulting in asymmetry between poles by mid-oogenesis. Interestingly, we found similar temporal dynamics at follicle poles in the accumulation of the adherens junction E-cadherin protein. Remarkably, E-cadherin and JAK-STAT signaling not only display patterning overlaps but also share functions during oogenesis. In particular, we show that E-cadherin, like JAK-STAT signaling, regulates polar cell apoptosis non-cell-autonomously from follicle cells. Finally, our work reveals that E-cadherin is required for optimal JAK-STAT activity throughout oogenesis and that E-cadherin and Stat92E, the transcription factor of the pathway, form part of a physical complex in follicle cells. Taken together, our study establishes E-cadherin as a new positive regulator of JAK-STAT signaling during oogenesis.
引用
收藏
页数:13
相关论文
共 50 条
  • [21] Identification of Novel Regulators of the JAK/STAT Signaling Pathway that Control Border Cell Migration in the Drosophila Ovary
    Saadin, Afsoon
    Starz-Gaiano, Michelle
    G3-GENES GENOMES GENETICS, 2016, 6 (07): : 1991 - 2002
  • [22] Intact JAK-STAT signaling pathway is a prerequisite for STAT1 to reinforce the expression of RIG-G gene
    Lou, Ye-Jiang
    Zhang, Zhang-Lin
    Pan, Xiao-Rong
    Xu, Gui-Ping
    Jia, Pei-Min
    Li, Dong
    Tong, Jian-Hua
    EXPERIMENTAL CELL RESEARCH, 2011, 317 (04) : 513 - 520
  • [23] The NEK1 gene regulates the JAK-STAT signaling pathway and promotes the proliferation of glioma cells
    Xia, Kailai
    Liu, Yan
    Tang, Hua
    Han, Jing
    Guan, Yuhua
    Zheng, Gang
    Chen, Shaojun
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2020, 13 (12): : 9353 - 9362
  • [24] Mechanism of JAK-STAT signaling pathway inhibitor in post-spinal cord injury
    Wang, Weidong
    Wang, Xinjia
    Chen, Kongguan
    Yao, Guanfeng
    Chen, Yuchun
    Zhou, Xueqiong
    Kong, Kangmei
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2016, 9 (03): : 3648 - 3653
  • [25] Phosphospecific flow cytometry for pharmacodynamic drug monitoring: Analysis of the JAK-STAT signaling pathway
    Vafadari, Ramin
    Weimar, Willem
    Baan, Carla C.
    CLINICA CHIMICA ACTA, 2012, 413 (17-18) : 1398 - 1405
  • [26] Prognostic value of key genes of the JAK-STAT signaling pathway in patients with cutaneous melanoma
    Pan, Fuqiang
    Wang, Qiaoqi
    Li, Sizhu
    Huang, Rui
    Wang, Xiangkun
    Liao, Xiwen
    Mo, Haiyan
    Zhang, Liming
    Zhou, Xiang
    ONCOLOGY LETTERS, 2020, 19 (03) : 1928 - 1946
  • [27] Role of JAK-STAT signaling pathway in pathogenesis and treatment of primary Sjogren's syndrome
    Li, Mucong
    Li, Mengtao
    Qiao, Lin
    Wu, Chanyuan
    Xu, Dong
    Zhao, Yan
    Zeng, Xiaofeng
    CHINESE MEDICAL JOURNAL, 2023, 136 (19) : 2297 - 2306
  • [28] Bufalin Promotes Apoptosis and Autophagy Through the JAK-STAT Signaling Pathway in Myeloid Leukemia
    Wu, Zelei
    Cui, Yunqing
    Mao, Weixin
    Li, Yingjun
    Memon, Muhmmad Azhar
    Lan, Hai
    PAKISTAN VETERINARY JOURNAL, 2024, 44 (04) : 1142 - 1152
  • [29] Inhibition of JAK-STAT Signaling Pathway Alleviates Age-Related Phenotypes in Tendon Stem/Progenitor Cells
    Chen, Minhao
    Xiao, Longfei
    Dai, Guangchun
    Lu, Panpan
    Zhang, Yuanwei
    Li, Yingjuan
    Ni, Ming
    Rui, Yunfeng
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
  • [30] Histone demethylase dUTX antagonizes JAK-STAT signaling to maintain proper gene expression and architecture of the Drosophila testis niche
    Tarayrah, Lama
    Herz, Hans-Martin
    Shilatifard, Ali
    Chen, Xin
    DEVELOPMENT, 2013, 140 (05): : 1014 - 1023