Synthesis and Anti-tumor Activity Evaluation of Rhein-Aloe Emodin Hybrid Molecule

被引：1
作者：
Yuan, Ye-fei [1 ,2 ,3 ]
Hu, Xiang-yu [2 ]
He, Ying [2 ]
Deng, Jia-gang [4 ]
机构：
[1] Guangxi Med Univ, Nanning 530021, Guangxi, Peoples R China
[2] Luzhou Med Coll, Luzhou 646000, Sichuan, Peoples R China
[3] Guangxi Boise Natl Agr Sci Tech Zone, Baise 533612, Guangxi, Peoples R China
[4] Guangxi Tradit Chinese Med Univ, Nanning 530001, Guangxi, Peoples R China
来源：
NATURAL PRODUCT COMMUNICATIONS | 2012年 / 7卷 / 02期
关键词：
Rhein; Aloe-emodin; Rhein-aloe emodin hybrid molecule; SQUAMOUS-CELL CARCINOMA; MECHANISMS; APOPTOSIS; DEATH;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
To improve the anti-tumor effects of rhein and aloe-emodin, a rhein-aloe-emodin hybrid molecule (RH-AE) was synthesized from rhein and aloe-emodin in the presence of dicyclohexylcarbodiimide (DCC) and 4-dimethylaminopyridine (DMAP). Chemical and spectroscopic methods, such as H-1 and C-13 NMR spectroscopy, and HR-ESIMS were used for the structure identification of RH-AE. Using the cell counting kit-8 (CCK-8) assay, the in vitro anti-tumor effects were compared between RH-AE, rhein and aloe-emodin on human hepatoma HepG2, human nasopharyngeal carcinoma CNE, human lung cancer NCI-H460, human ovarian cancer SK-OV-3, and human cervical cancer Hela cells. The results showed that the half inhibitory concentration (IC50) of RH-AE on HepG2, CNE, NCI-H460, SK-OV-3, and Hela cells were significantly lower than those of rhein and aloe-emodin. This showed that RH-AE has a better in vitro anti-tumor effect than rhein and aloe-emodin.
引用
收藏
页码：207 / 210
页数：4
相关论文
共 50 条
  • [41] Synthesis, Anti-Tumor and Anti-Angiogenic Activity Evaluations of Asiatic Acid Amino Acid Derivatives
    Jing, Yue
    Wang, Gang
    Ge, Ying
    Xu, Minjie
    Gong, Zhunan
    MOLECULES, 2015, 20 (04) : 7309 - 7324
  • [42] Insights into the Biological Evaluation of Pterocarpanquinones and Carbapterocarpans with Anti-tumor Activity against MDR Leukemias
    Rumjanek, Vivian M.
    Maia, Raquel C.
    Salustiano, Eduardo J.
    Costa, Paulo R. R.
    ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2019, 19 (01) : 29 - 37
  • [43] Anti-tumor activity evaluation of novel tubulin and HDAC dual-targeting inhibitors
    Wang, Baolei
    Chen, Xuehong
    Gao, Jianjun
    Su, Li
    Zhang, Li
    Xu, Hongwei
    Luan, Yepeng
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 29 (18) : 2638 - 2645
  • [44] Synthesis and in vitro biological evaluation of novel dendrocandin analogue as potential anti-tumor agent
    Yan, Jing-Yun
    Yang, Hao-Nan
    Yang, Ning
    Xie, Yin-Rong
    Sun, Xiu-Li
    Huang, Ye-Wei
    Zi, Cheng-Ting
    Wang, Xuan-Jun
    Sheng, Jun
    NATURAL PRODUCT RESEARCH, 2022, 36 (15) : 3951 - 3956
  • [45] Anti-tumor activity of phenoxodiol: from bench to clinic
    Alvero, Ayesha B.
    Kelly, Michael
    Rossi, Patti
    Leiser, Aliza
    Brown, David
    Rutherford, Thomas
    Mor, Gil
    FUTURE ONCOLOGY, 2008, 4 (04) : 475 - 482
  • [46] In Vitro Anti-tumor Activity of Azulene Amide Derivatives
    Wada, Toshiki
    Maruyama, Ryota
    Irie, Yuta
    Hashimoto, Masashi
    Wakabayashi, Hidetsugu
    Okudaira, Noriyuki
    Uesawa, Yoshihiro
    Kagaya, Hajime
    Sakagami, Hiroshi
    IN VIVO, 2018, 32 (03): : 479 - 486
  • [47] Anti-tumor activity of safranal against neuroblastoma cells
    Samarghandian, Saeed
    Shoshtari, Mohammad Ebrahim
    Sargolzaei, Javad
    Hossinimoghadam, Hosna
    Farahzad, Jabbari Azad
    PHARMACOGNOSY MAGAZINE, 2014, 10 (38) : 419 - 424
  • [48] Study on Anti-tumor Activity of Mitissimol D in vitro
    Cao, Zhi-Ran
    Bei-Wang
    Rong, Rui-Xue
    Wang, Hai
    Wang, Yong-Li
    Luo, Du-Qiang
    ISBE 2011: 2011 INTERNATIONAL CONFERENCE ON BIOMEDICINE AND ENGINEERING, VOL 1, 2011, : 222 - 225
  • [49] Anti-tumor activity of the methanolic extracts of Salvia menthifolia
    Fiore, Giovina
    Massarelli, Paola
    Sajeva, Maurizio
    Franchi, Gian Gabriele
    REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2012, 22 (02): : 381 - 388
  • [50] Study on anti-tumor activity of Stigmatella WXNXJ-B in vitro and qualitative analysis of its anti-tumor components
    Wang, Dahong
    Qin, Cuili
    Yuan, Jiangfeng
    Gu, Shaobin
    AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH, 2012, 6 (08): : 1877 - 1883
12345