Tumors masquerading as type 2 papillary renal cell carcinoma: pathologists' ever-expanding differential diagnosis for a heterogeneous group of entities

被引：2
|
作者：
Taylor, Alexander S. [1 ]
Skala, Stephanie L. [1 ]
机构：
[1] Univ Michigan, Med Sch, Dept Pathol, Ann Arbor, MI 48109 USA
来源：
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | 2022年 / 40卷 / 12期
关键词：
Type 2 papillary renal cell carcinoma; Renal cell carcinoma; Renal tumor classification; COLLECTING DUCT CARCINOMA; COMPREHENSIVE MOLECULAR CHARACTERIZATION; BREAK-APART FISH; HEREDITARY LEIOMYOMATOSIS; GENE FUSION; CATHEPSIN-K; INTERNATIONAL SOCIETY; EPITHELIAL NEOPLASMS; MORPHOLOGIC SPECTRUM; MEDULLARY CARCINOMA;
D O I：
10.1016/j.urolonc.2021.04.043
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Although papillary renal cell carcinoma has historically been classified as either type 1 or type 2, data from The Cancer Genome Atlas (TCGA) has demonstrated significant genomic heterogeneity in tumors classified as "type 2 papillary renal cell carcinoma " (T2PRCC). Papillary renal cell carcinoma is expected to have a favorable clinical course compared to clear cell renal cell carcinoma (CCRCC). However, tumors with poor outcome more similar to CCRCC were included in the T2PRCC cohort studied by the TCGA. The differential diagnosis for T2PRCC includes a variety of other renal tumors, including aggressive entities such as TFE3 translocation-associated renal cell carcinoma, TFEB-amplified renal cell carcinoma, fumarate hydratase-deficient renal cell carcinoma, high-grade CCRCC, and collecting duct carcinoma. Accurate classification of these tumors is important for prognostication and selection of therapy. (C) 2021 Elsevier Inc. All rights reserved.
引用
收藏
页码：499 / 511
页数：13
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