Rab5 Proteins Regulate Activation and Localization of Target of Rapamycin Complex 1

被引：54
作者：
Bridges, Dave [1 ]
Fisher, Kaleigh [1 ]
Zolov, Sergey N. [1 ]
Xiong, Tingting [1 ,3 ]
Inoki, Ken [1 ,3 ]
Weisman, Lois S. [1 ,4 ]
Saltiel, Alan R. [1 ,2 ,4 ]
机构：
[1] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA
来源：
JOURNAL OF BIOLOGICAL CHEMISTRY | 2012年 / 287卷 / 25期
基金：
美国国家卫生研究院;
关键词：
P70; S6; KINASE; SACCHAROMYCES-CEREVISIAE; AMINO-ACIDS; PHOSPHATIDYLINOSITOL 3,5-BISPHOSPHATE; ACTIN CYTOSKELETON; PHOSPHOLIPASE-D; GENE-PRODUCTS; LIPID KINASE; CELL-GROWTH; RAG GTPASES;
D O I：
10.1074/jbc.M111.334060
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mechanistic target of rapamycin (mTOR) complex 1 is regulated by small GTPase activators and localization signals. We examine here the role of the small GTPase Rab5 in the localization and activation of TORC1 in yeast and mammalian cells. Rab5 mutants disrupt mTORC1 activation and localization in mammalian cells, whereas disruption of the Rab5 homolog in yeast, Vps21, leads to decreased TORC1 function. Additionally, regulation of PI(3)P synthesis by Rab5 and Vps21 is essential for TORC1 function in both contexts.
引用
收藏
页码：20913 / 20921
页数：9
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