On the formation of steroidal amidoesters of 4-[N,N-bis(2-chloroethyl)amino]benzoic acid and their cytotoxic activity

被引：10
作者：
Camoutsis, C [1 ]
Sambani, C
Trafalis, DTP
Peristeris, P
机构：
[1] Univ Patras, Dept Pharm, Lab Pharmaceut Chem, Patras 26100, Greece
[2] NCSR Demokritos, Inst NT RP, Hlth Phys & Environm Hyg Unit, Athens 15310, Greece
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1999年 / 34卷 / 7-8期
关键词：
steroidal; 4-[N; N-bis(2-chloroethyl)amino]benzoate amidoesters; MTT assay; cytotoxicity; MIA Pa-Ca-2; T47D; A431; cells;
D O I：
10.1016/S0223-5234(00)80033-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The 4-[N,N-bis(2-chloroethyl)amino]benzoate of 17 beta-acetamido-5 alpha-androstan-3 beta-ol, 17 beta-acetamido-5-androsten-3 beta-ol, 3 beta-acetamido-5 alpha-androstan-17 beta-ol and 3 alpha-acetamido-5 beta-androstan-17 beta-ol have been prepared and their antineoplastic effect evaluated against MIA Pa-Ca-2 pancreatic carcinoma, T47D breast carcinoma and A431 squamus cell carcinoma. Among the compounds tested, the compound 17 beta-acetamido-3 beta-hydroxy-5-androsten-4-[N-bis(2-chloroethyl)amino]benzoate appeared to possess a significant cytotoxic effect against A431 cells. (C) 1999 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码：645 / 649
页数：5
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