Postpartum Anti-N-methyl-D-aspartate Receptor Encephalitis: A Case Report and Literature Review

被引：13

作者：

Doden, Tadashi ^{[1
]}

Sekijima, Yoshiki ^{[1
,2
]}

Ikeda, Junji ^{[1
]}

Ozawa, Kazuki ^{[1
]}

Ohashi, Nobuhiko ^{[1
]}

Kodaira, Minori ^{[1
]}

Hineno, Akiyo ^{[1
,3
]}

Tachibana, Naoko ^{[4
]}

Ikeda, Shu-ichi ^{[1
,2
]}

机构：

[1] Shinshu Univ, Sch Med, Dept Med Neurol & Rheumatol, Matsumoto, Nagano, Japan

[2] Shinshu Univ, Inst Biomed Sci, Matsumoto, Nagano, Japan

[3] Suwa Red Cross Hosp, Dept Neurol, Suwa, Japan

[4] Okaya City Hosp, Dept Neurol, Okaya, Japan

来源：

INTERNAL MEDICINE | 2017年 / 56卷 / 03期

关键词：

anti-N-methyl-D-aspartate receptor encephalitis; parturition; ovarian teratoma; NEUROMYELITIS-OPTICA; NMDAR ENCEPHALITIS; PREGNANCY; PSYCHOSIS; ANTIBODIES;

D O I：

10.2169/internalmedicine.56.7442

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe a 24-year-old woman with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis that developed 3 weeks after normal delivery. She was treated with methylprednisolone, intravenous immunoglobulin, and plasmapheresis, in addition to teratoma excision. However, her recovery was slow, and dysmnesia and mental juvenility persisted even two years after onset. To date, five patients with postpartum anti-NMDAR encephalitis have been reported. All of those patients showed psychotic symptoms and were suspected of having postpartum psychosis in the early period of the encephalitis. Changes in hormonal factors, modification of immune tolerance, or retrograde infection of the ovary may be contributing factors for postpartum anti-NMDAR encephalitis.

引用

页码：357 / 362

页数：6

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