Meta-Analysis of the Correlation Between PTPN22 Gene Polymorphisms and Susceptibility to Systemic Lupus Erythematosus

被引：8

作者：

Shi, Lipu ^{[1
]}

Wei, Yanlin ^{[1
]}

Xun, Wen ^{[1
]}

Han, Dan ^{[1
]}

机构：

[1] Peoples Hosp Zhengzhou, Zhengzhou 450000, Peoples R China

来源：

ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH | 2013年 / 25卷 / S4期

关键词：

PTPN22; gene; systemic lupus erythematosus (SLE); 1858C; T polymorphism; meta-analysis; PROTEIN-TYROSINE-PHOSPHATASE; SINGLE-NUCLEOTIDE POLYMORPHISM; RHEUMATOID-ARTHRITIS; AUTOIMMUNE-DISEASE; CELL TOLERANCE; ASSOCIATION; POPULATION; ALLELE; ONSET;

D O I：

10.1177/1010539513496268

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

In this meta-analysis of the association between PTPN22 gene polymorphisms and susceptibility to systemic lupus erythematosus, 4 case-control studies, including one from China, were included. The studies included 1864 participants: 772 cases and 1092 controls. The meta-analysis showed that the 1858C/T polymorphism of the PTPN22 gene is correlated with systemic lupus erythematosus susceptibility, when assessed by distribution characteristics such as nationality, race, and region. A large sample size from the Chinese population is required for a further prospective study before causality can be established.

引用

页码：22S / 29S

页数：8

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