Meta-Analysis of the Correlation Between PTPN22 Gene Polymorphisms and Susceptibility to Systemic Lupus Erythematosus

被引：8

作者：

Shi, Lipu ^{[1
]}

Wei, Yanlin ^{[1
]}

Xun, Wen ^{[1
]}

Han, Dan ^{[1
]}

机构：

[1] Peoples Hosp Zhengzhou, Zhengzhou 450000, Peoples R China

来源：

ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH | 2013年 / 25卷 / S4期

关键词：

PTPN22; gene; systemic lupus erythematosus (SLE); 1858C; T polymorphism; meta-analysis; PROTEIN-TYROSINE-PHOSPHATASE; SINGLE-NUCLEOTIDE POLYMORPHISM; RHEUMATOID-ARTHRITIS; AUTOIMMUNE-DISEASE; CELL TOLERANCE; ASSOCIATION; POPULATION; ALLELE; ONSET;

D O I：

10.1177/1010539513496268

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

In this meta-analysis of the association between PTPN22 gene polymorphisms and susceptibility to systemic lupus erythematosus, 4 case-control studies, including one from China, were included. The studies included 1864 participants: 772 cases and 1092 controls. The meta-analysis showed that the 1858C/T polymorphism of the PTPN22 gene is correlated with systemic lupus erythematosus susceptibility, when assessed by distribution characteristics such as nationality, race, and region. A large sample size from the Chinese population is required for a further prospective study before causality can be established.

引用

页码：22S / 29S

页数：8

共 21 条

[1] Association analysis of the PTPN22 gene in childhood-onset systemic lupus erythematosus in Mexican population [J].

Baca, V. ;

Velazquez-Cruz, R. ;

Salas-Martinez, G. ;

Espinosa-Rosales, F. ;

Saldana-Alvarez, Y. ;

Orozco, L. .

GENES AND IMMUNITY, 2006, 7 (08) :693-695

[2] The codon 620 single nucleotide polymorphism of the protein tyrosine phosphatase-22 gene does not contribute to autoimmune thyroid disease susceptibility in the Japanese [J].

Ban, Y ;

Tozaki, T ;

Taniyama, M ;

Tomita, M ;

Ban, Y .

THYROID, 2005, 15 (10) :1115-1118

[3]

Cheng YL, 2010, CHIN J LEPROSY SKIN, V26, P774

[4] Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp [J].

Cohen, S ;

Dadi, H ;

Shaoul, E ;

Sharfe, N ;

Roifman, CM .

BLOOD, 1999, 93 (06) :2013-2024

[5] Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection:: the PTPN22 620W allele associates with multiple autoimmune phenotypes [J].

Criswell, LA ;

Pfeiffer, KA ;

Lum, RF ;

Gonzales, B ;

Novitzke, J ;

Moser, KL ;

Begovich, AB ;

Carlton, VEH ;

Li, W ;

Lee, AT ;

Ortmann, W ;

Behrens, TW ;

Gregersen, PK .

AMERICAN JOURNAL OF HUMAN GENETICS, 2005, 76 (04) :561-571

[6]

Hu BC, 2008, CENT CHIN MED J, V32, P12

[7] PTPN22 polymorphism and anti-cyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease [J].

Johansson, M ;

Ärlestig, L ;

Hallmans, G ;

Rantapää-Dahlqvist, S .

ARTHRITIS RESEARCH & THERAPY, 2006, 8 (01)

[8] Non-Major Histocompatibility Complex Rheumatoid Arthritis Susceptibility Genes [J].

Kunz, Manfred ;

Ibrahim, Saleh M. .

CRITICAL REVIEWS IN IMMUNOLOGY, 2011, 31 (02) :99-114

[9] Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE [J].

Kyogoku, C ;

Langefeld, CD ;

Ortmann, WA ;

Lee, A ;

Selby, S ;

Carlton, VEH ;

Chang, M ;

Ramos, P ;

Baechler, EC ;

Batliwalla, FM ;

Novitzke, J ;

Williams, AH ;

Gillett, C ;

Rodine, P ;

Graham, RR ;

Ardlie, KG ;

Gaffney, PM ;

Moser, KL ;

Petri, M ;

Begovich, AB ;

Gregersen, PK ;

Behrens, TW .

AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 75 (03) :504-507

[10] Genetic lesions in T-cell tolerance and thresholds for autoimmunity [J].

Liston, A ;

Lesage, S ;

Gray, DHD ;

Boyd, RL ;

Goodnow, CC .

IMMUNOLOGICAL REVIEWS, 2005, 204 :87-101

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