Meta-Analysis of the Correlation Between PTPN22 Gene Polymorphisms and Susceptibility to Systemic Lupus Erythematosus

被引：8
|
作者：
Shi, Lipu [1 ]
Wei, Yanlin [1 ]
Xun, Wen [1 ]
Han, Dan [1 ]
机构：
[1] Peoples Hosp Zhengzhou, Zhengzhou 450000, Peoples R China
来源：
ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH | 2013年 / 25卷 / S4期
关键词：
PTPN22; gene; systemic lupus erythematosus (SLE); 1858C; T polymorphism; meta-analysis; PROTEIN-TYROSINE-PHOSPHATASE; SINGLE-NUCLEOTIDE POLYMORPHISM; RHEUMATOID-ARTHRITIS; AUTOIMMUNE-DISEASE; CELL TOLERANCE; ASSOCIATION; POPULATION; ALLELE; ONSET;
D O I：
10.1177/1010539513496268
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
In this meta-analysis of the association between PTPN22 gene polymorphisms and susceptibility to systemic lupus erythematosus, 4 case-control studies, including one from China, were included. The studies included 1864 participants: 772 cases and 1092 controls. The meta-analysis showed that the 1858C/T polymorphism of the PTPN22 gene is correlated with systemic lupus erythematosus susceptibility, when assessed by distribution characteristics such as nationality, race, and region. A large sample size from the Chinese population is required for a further prospective study before causality can be established.
引用
收藏
页码：22S / 29S
页数：8
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