Treatment of experimental staphylococcal endocarditis due to a strain with reduced susceptibility in vitro to vancomycin: Efficacy of ampicillin-sulbactam

被引：25
作者：
Backo, M
Gaenger, E
Burkart, A
Chai, YL
Bayer, AS
机构：
[1] Harbor UCLA Med Ctr, Div Adult Infect Dis, Torrance, CA 90509 USA
[2] Harbor UCLA Med Ctr, St Johns Cardiovasc Res Ctr, Torrance, CA 90509 USA
[3] Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90024 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 10期
关键词：
D O I：
10.1128/AAC.43.10.2565
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We evaluated several 3-day antimicrobial regimens in the treatment of experimental endocarditis caused by an oxacillin-resistant Staphylococcus aureus strain exhibiting intermediate susceptibility in vitro to vancomycin (VISA). Neither vancomycin alone nor trovafloxacin exhibited in vivo efficacy; addition of amikacin to vancomycin yielded a modest in vivo effect. In contrast, the combination of ampicillin and sulbactam was highly effective in vivo, causing a mean decrease in VISA vegetation densities of >5 log(10) CFU/g versus those of untreated controls.
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收藏
页码：2565 / 2568
页数：4
相关论文
共 22 条
[1]   Efficacy of trovafloxacin, a new quinolone antibiotic, in experimental staphylococcal endocarditis due to oxacillin-resistant strains [J].
Bayer, AS ;
Li, C ;
Ing, M .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (07) :1837-1841
[2]   CHEMOPROPHYLACTIC EFFICACY AGAINST EXPERIMENTAL ENDOCARDITIS CAUSED BY BETA-LACTAMASE-PRODUCING, AMINOGLYCOSIDE-RESISTANT ENTEROCOCCI IS ASSOCIATED WITH PROLONGED SERUM INHIBITORY ACTIVITY [J].
BAYER, AS ;
TU, J .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (06) :1068-1074
[3]   COMPARATIVE PHARMACOKINETICS AND PHARMACODYNAMICS OF AMIKACIN AND CEFTAZIDIME IN TRICUSPID AND AORTIC VEGETATIONS IN EXPERIMENTAL PSEUDOMONAS ENDOCARDITIS [J].
BAYER, AS ;
CROWELL, DJ ;
YIH, J ;
BRADLEY, DW ;
NORMAN, DC .
JOURNAL OF INFECTIOUS DISEASES, 1988, 158 (02) :355-359
[4]   PATHOGENIC EFFECTS OF MONOCYTOPENIA, GRANULOCYTOPENIA AND DEXAMETHASONE ON THE COURSE OF EXPERIMENTAL PSEUDOMONAS-AERUGINOSA ENDOCARDITIS IN RABBITS [J].
BAYER, AS ;
YIH, J ;
CHIU, CY ;
NAST, CC .
CHEMOTHERAPY, 1989, 35 (04) :278-288
[5]   EFFICACY OF VANCOMYCIN PLUS RIFAMPIN IN EXPERIMENTAL AORTIC-VALVE ENDOCARDITIS DUE TO METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS - INVITRO INVIVO CORRELATIONS [J].
BAYER, AS ;
LAM, K .
JOURNAL OF INFECTIOUS DISEASES, 1985, 151 (01) :157-165
[6]   VALVE SITE-SPECIFIC PATHOGENETIC DIFFERENCES BETWEEN RIGHT-SIDED AND LEFT-SIDED BACTERIAL-ENDOCARDITIS [J].
BAYER, AS ;
NORMAN, DC .
CHEST, 1990, 98 (01) :200-205
[7]  
Centers for Disease Control and Prevention (CDC), 1997, MMWR Morb Mortal Wkly Rep, V46, P813
[8]  
Centers for Disease Control and Prevention (CDC), 1997, MMWR MORB MORTAL WKL, V46, P765
[9]   THERAPY OF EXPERIMENTAL PSEUDOMONAS ENDOCARDITIS WITH HIGH-DOSE AMIKACIN AND TICARCILLIN [J].
CHOI, C ;
BAYER, AS ;
FUJITA, NK ;
LAM, K ;
GUZE, LB ;
YOSHIKAWA, TT .
CHEMOTHERAPY, 1983, 29 (04) :303-312
[10]   Lysostaphin treatment of experimental methicillin-resistant Staphylococcus aureus aortic valve endocarditis [J].
Climo, MW ;
Patron, RL ;
Goldstein, BP ;
Archer, GL .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (06) :1355-1360
123