MSCs can be a double-edged sword in tumorigenesis

被引：21

作者：

Zhang, Lu ^{[1
]}

Xiang, Junyu ^{[2
]}

Zhang, Fang ^{[1
]}

Liu, Limei ^{[1
]}

Hu, Chongling ^{[3
]}

机构：

[1] Chongqing Univ, Canc Hosp, Oncol Lab, Chongqing Key Lab Translat Res Metastasis & Indiv, Chongqing, Peoples R China

[2] Third Mil Med Univ, Dept Biomed Mat Sci, Chongqing, Peoples R China

[3] Chongqing Univ, Canc Hosp, Hematol Oncol Ctr, Chongqing, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 12卷

关键词：

mesenchymal stem cells; cancer immunotherapy; extracellular vesicles; innate immune cells; adaptive immune cells; MESENCHYMAL STEM-CELLS; BREAST-CANCER METASTASIS; STROMAL CELLS; MACROPHAGES; PROMOTES; INHIBIT; PROGRESSION; ACTIVATION; DIFFERENTIATION; MATURATION;

D O I：

10.3389/fonc.2022.1047907

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mesenchymal stem cells (MSCs) have been used to treat various diseases including Alzheimer's disease and cancer. In particular, the immunomodulatory function of MSCs plays a major role in cancer therapy using stem cells. However, MSCs exert promotive and inhibitory effects on cancer. The immunomodulatory effects of MSCs in the tumor microenvironment (TME) are ambiguous, which is the primary reason for the different outcomes of MSCs therapies for tumors. This review discusses the use of MSCs in cancer immunotherapy and their immunomodulatory mechanisms in cancers.

引用

页数：12

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