Cu,Zn-superoxide dismutase gene dosage and cell resistance to oxidative stress: A review

被引：15
作者：
Peskin, AV
机构：
[1] Institute of Developmental Biology, Russian Academy of Sciences
来源：
BIOSCIENCE REPORTS | 1997年 / 17卷 / 01期
关键词：
superoxide dismutase; catalase; oxygen radicals; oxidative stress; carcinogenesis; gene transfection;
D O I：
10.1023/A:1027343519591
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
It is well established that superoxide dismutase (SOD) is the irresplaceable enzyme far aerobic lifestyle. Our understanding of its role has made strides recently as the result of gene transfection approach. Available data on consequences of Cu,Zn-SOD gene transfection in cell resistance to oxygen toxicity are reviewed. There are data that increasing only Cu,Zn-SOD can be toxic, and the balance between Cu,Zn-SOD and peroxide-removing enzymes is supposed to be of prime importance in the antioxidant defence. Role of Cu,Zn-SOD deregulation in carcinogenesis is discussed.
引用
收藏
页码：85 / 89
页数：5
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