Dual T1/T2 MRI contrast agent based on hybrid SPION@coordination polymer nanoparticles

被引：32
作者：
Borges, M. [1 ,2 ]
Yu, S. [3 ]
Laromaine, A. [3 ]
Roig, A. [3 ]
Suarez-Garcia, S. [1 ,2 ]
Lorenzo, J. [4 ]
Ruiz-Molina, D. [1 ,2 ]
Novio, F. [1 ,2 ]
机构：
[1] CSIC, ICN2, Barcelona 08193, Spain
[2] Barcelona Inst Sci & Technol, Barcelona 08193, Spain
[3] CSIC, ICMAB, Inst Ciencia Mat Barcelona, Barcelona 08193, Spain
[4] UAB, IBB, Dept Bioquim & Biol Mol, Barcelona 08193, Spain
来源：
RSC ADVANCES | 2015年 / 5卷 / 105期
关键词：
IRON-OXIDE NANOPARTICLES; NEPHROGENIC SYSTEMIC FIBROSIS; METAL-ORGANIC FRAMEWORKS; MAGNETITE NANOPARTICLES; FE3O4; NANOPARTICLES; ASSISTED SYNTHESIS; COMPLEXES; T-1; RELAXIVITY; POLY(LACTIDE-CO-GLYCOLIDE);
D O I：
10.1039/c5ra17661a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report a novel hybrid T-1/T-2 dual MRI contrast agent by the encapsulation of SPIONs (T-2 contrast agent) into an iron-based coordination polymer with T-1-weighted signal. This new hybrid material presents improved relaxometry and low cytotoxicity, which make it suitable for its use as contrast agent for MRI.
引用
收藏
页码：86779 / 86783
页数：5
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