The Novel Antipsychotic Cariprazine (RGH-188): State-of-the-Art in the Treatment of Psychiatric Disorders

被引：21

作者：

De Berardis, Domenico ^{[1
,2
]}

Orsolini, Laura ^{[3
,4
,5
]}

Iasevoli, Felice ^{[6
]}

Prinzivalli, Emiliano ^{[6
]}

de Bartolomeis, Andrea ^{[6
]}

Serroni, Nicola ^{[2
]}

Mazza, Monica ^{[7
]}

Valchera, Alessandro ^{[4
,5
]}

Fornaro, Michele ^{[8
,9
]}

Vecchiotti, Roberta ^{[4
,5
]}

Carano, Alessandro ^{[10
]}

Sepede, Gianna ^{[2
,11
]}

Vellante, Federica ^{[1
,2
]}

Matarazzo, Ilaria ^{[1
,2
]}

Pompili, Maurizio ^{[12
]}

Perna, Giampaolo ^{[13
,14
,15
]}

Conti, Chiara ^{[16
]}

Segura-Garcia, Cristina ^{[17
]}

Martinotti, Giovanni ^{[2
]}

Di Giannantonio, Massimo ^{[2
]}

机构：

[1] ASL 4 Teramo, Hosp G Mazzini, Psychiat Serv Diag & Treatment, NHS,Dept Mental Hlth, Teramo, Italy

[2] Univ G DAnnunzio, Dept Neurosci & Imaging, Chieti, Italy

[3] Univ Hertfordshire, Sch Life & Med Sci, Hatfield, Herts, England

[4] Polyedra, Teramo, Italy

[5] Hermanas Hosp, Villa S Giuseppe Hosp, Ascoli Piceno, Italy

[6] Univ Sch Med Federico II, Dept Neurosci, Sect Psychiat, Lab Mol Psychiat & Psychopharmacotherapeut, Naples, Italy

[7] Univ Aquila, Dept Hlth Sci, Laquila, Italy

[8] Columbia Univ, New York State Psychiat Inst, New York, NY USA

[9] Univ Catania, Dept Educ Sci, Catania, Italy

[10] Hosp Madonna Del Soccorso, NHS, Psychiat Serv Diag & Treatment, Dept Mental Hlth, San Benedetto Tronto, Ascoli Piceno, Italy

[11] Univ A Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy

[12] Sapienza Univ Rome, St Andrea Hosp, Suicide Prevent Ctr, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy

[13] Villa San Benedetto Menni, Hermanas Hosp, Dept Clin Neurosci, FoRiPsi, Albese Con Cassano, Como, Italy

[14] Maastricht Univ, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

[15] Univ Miami, Leonard Miller Sch Med, Dept Psychiat & Behav Sci, Coral Gables, FL 33124 USA

[16] Univ G DAnnunzio, Dept Psychol Humanistic & Terr Sci DiSPUTer, Chieti, Italy

[17] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Univ Salvatore Venuta, Catanzaro, Italy

来源：

CURRENT PHARMACEUTICAL DESIGN | 2016年 / 22卷 / 33期

关键词：

Cariprazine; RGH-188; MP-214; Dopamine D-3/D-2 ligand; Schizophrenia; Bipolar Disorder; Major Depressive Disorder; antipsychotic; DOPAMINE D-3 RECEPTOR; BIPOLAR I DISORDER; PARTIAL AGONIST; ACUTE MANIA; CLINICAL-EFFICACY; DOUBLE-BLIND; PHASE-III; PHARMACOLOGICAL TARGET; ANTIMANIC TREATMENTS; RECOGNITION MEMORY;

D O I：

10.2174/1381612822666160701084447

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cariprazine (RGH-188) is a novel antipsychotic drug that exerts partial agonism of dopamine D-2/D-3 receptors with preferential binding to D-3 receptor, antagonism of 5HT(2B) receptors and partial agonism of 5HT(1A). Currently, cariprazine is in late-stage clinical development (phase III clinical trials) in patients with schizophrenia (S) and in patients with bipolar disorder (BD), as well as an adjunctive treatment in patients with Major Depressive Disorder (MDD) and drug-resistant MDD. Cariprazine has completed phase III trials for the acute treatment of schizophrenia and bipolar mania, phase II trials for the bipolar depression and MDD whilst it is undergoing phase III trials as an adjunct to antidepressants. The present review aims at proving a comprehensive summary of the current evidence on the safety, tolerability and efficacy of cariprazine in the treatment of schizophrenia, BD (manic/mixed/depressive episode) and MDD. A systematic search was conducted on PubMed/Medline/Scopus and the database on Clinical Trials from inception until April 2015 by typing a set of specified keywords. Available evidence seems to support cariprazine efficacy in the treatment of cognitive and negative symptoms of schizophrenia. Preliminary findings suggest its antimanic activity whilst it is still under investigation its efficacy in the treatment of bipolar depression and MDD. Furthermore, the available data seems not to allow judgements about its antipsychotic potential in comparison with currently prescribed antipsychotics. Further studies should be carried out to better investigate its pharmacodynamic and clinical potential, particularly as alternative to current antipsychotic drugs.

引用

页码：5144 / 5162

页数：19

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