Mechanotransduction of stem cells for tendon repair

被引：21
作者：
Wang, Hao-Nan [1 ]
Huang, Yong-Can [2 ,3 ]
Ni, Guo-Xin [1 ]
机构：
[1] Beijing Sport Univ, Sch Sport Med & Rehabil, 48 Xinxi Rd, Beijing 100084, Peoples R China
[2] Peking Univ, Dept Spine Surg, Shenzhen Engn Lab Orthopaed Regenerat Technol, Shenzhen Hosp, Shenzhen 518036, Guangdong, Peoples R China
[3] Peking Univ, Shenzhen Hosp, Natl & Local Joint Engn Res Ctr Orthopaed Biomat, Shenzhen 518036, Guangdong, Peoples R China
来源：
WORLD JOURNAL OF STEM CELLS | 2020年 / 12卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Stem cells; Mechanical loading; Tendon repair; Mechanotransduction; PROMOTED OSTEOGENIC DIFFERENTIATION; MESENCHYMAL STROMAL CELLS; TENOGENIC DIFFERENTIATION; BONE-MARROW; MECHANICAL STIMULATION; STEM/PROGENITOR CELLS; STRESS-DEPRIVATION; IN-VITRO; TENDINOPATHY; INJURY;
D O I：
10.4252/wjsc.v12.i9.952
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Tendon is a mechanosensitive tissue that transmits force from muscle to bone. Physiological loading contributes to maintaining the homeostasis and adaptation of tendon, but aberrant loading may lead to injury or failed repair. It is shown that stem cells respond to mechanical loading and play an essential role in both acute and chronic injuries, as well as in tendon repair. In the process of mechanotransduction, mechanical loading is detected by mechanosensors that regulate cell differentiation and proliferationviaseveral signaling pathways. In order to better understand the stem-cell response to mechanical stimulation and the potential mechanism of the tendon repair process, in this review, we summarize the source and role of endogenous and exogenous stem cells active in tendon repair, describe the mechanical response of stem cells, and finally, highlight the mechanotransduction process and underlying signaling pathways.
引用
收藏
页码：952 / 965
页数：14
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