Chemical constituents from Cistanche sinensis (Orobanchaceae)

Phytochemical investigation of 70% aqueous EtOH extract of Cistanche sinensis led to the isolation of fifteen compounds (1-15), including nine phenylethanoid glycosides (PhGs, 1-9), five iridoid glycosides (10-14), and one lignan glycoside (15). Their structures were determined on the basis of 1D- and 2D-NMR experiments and by comparison with physical data of known compounds. Among the isolated compounds, 1 was identified as a new compound, three compounds (9, 14, and 15) were firstly reported from the genus Cistanche, and seven compounds (2-6, 11, and 12) were isolated from C sinensis for the first time. PhGs with a 6'-O-rhamnosyl moiety such as cistansinenside B (1), poliumoside (7), and 2'-O-acetylpoliumoside (9) could serve as chemotaxonomic markers to differentiate C sinensis from other species of Cistanche. (C) 2012 Published by Elsevier Ltd.