Amniotic fluid induces platelet-neutrophil aggregation and neutrophil activation

被引:10
|
作者
Chen, Kuen-Bao [1 ]
Chang, Shih-Sheng [2 ,3 ]
Tseng, Yu-Lun [2 ,4 ]
Chiu, Tsan-Hung [5 ]
Liao, Cheng-Chun [1 ]
Ho, Ming [5 ]
Huang, Go-Shine [6 ]
Li, Chi-Yuan [1 ,2 ]
机构
[1] China Med Univ Hosp, Dept Anesthesiol, Taichung 40447, Taiwan
[2] China Med Univ, Grad Inst Clin Med Sci, Taichung, Taiwan
[3] China Med Univ Hosp, Dept Med, Div Cardiol, Taichung 40447, Taiwan
[4] China Med Univ Hosp, Dept Psychiat, Taichung 40447, Taiwan
[5] China Med Univ Hosp, Dept Obstet & Gynecol, Taichung 40447, Taiwan
[6] Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Anesthesiol, Taipei, Taiwan
关键词
amniotic fluid embolism syndrome (AFES); neutrophil activation; p38 mitogen-activated protein kinase (MAPK); platelet-neutrophil aggregation; P-SELECTIN; SIGNALING PATHWAYS; ENDOTHELIAL-CELLS; CALCIUM; EMBOLISM; INFLAMMATION; MOBILIZATION; MECHANISMS; FILTRATION; ADHESION;
D O I
10.1016/j.ajog.2013.01.012
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: Amniotic fluid embolism syndrome is a fatal disease in pregnant women. The exact role of platelets and neutrophils in amniotic fluid embolism syndrome is not clear. We examined whether amniotic fluid could affect platelet-neutrophil aggregation and activation and the possible mechanisms. STUDY DESIGN: Blood samples from the pregnant women were pretreated ex vivo with their own amniotic fluid. Flow cytometry was used to measure platelet-neutrophil aggregation and activation. Neutrophil-mediated activity of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinases 1 and 2 was analyzed by Western blotting. RESULTS: Amniotic fluid significantly induced platelet-neutrophil aggregation, neutrophil CD11b expression, and reactive oxygen species production. Amniotic fluid induced minimal platelet P-selectin expression. The increase of intracellular calcium level of neutrophils and the activity of p38 mitogen-activated protein kinase were enhanced by amniotic fluid stimulation. CONCLUSION: Amniotic fluid was able to induce neutrophil activation and platelet-neutrophil aggregation with minimal effect on platelet activation. These findings may provide a new insight in the understanding of the pathophysiologic condition of amniotic fluid embolism syndrome.
引用
收藏
页码:318.e1 / 318.e7
页数:7
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