Methylation of cytochrome p450 2E1 promoter induced by low dosage of isoniazid

被引：11
|
作者：
Shen, Lihong [1 ,2 ]
Zhang, Bing [3 ]
Sun, Shufeng [4 ]
Feng, Fumin [4 ]
机构：
[1] Commun Univ China, Beijing 100024, Peoples R China
[2] Hebei United Univ, Tangshan 063000, Peoples R China
[3] Tangshan Peoples Hosp, Tangshan 063000, Peoples R China
[4] Hebei United Univ, Sch Publ Hlth, Tangshan 063000, Peoples R China
来源：
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2013年 / 36卷 / 01期
关键词：
Methylation; Isoniazid; Liver injury; LUNG TUMORIGENESIS;
D O I：
10.1016/j.etap.2013.03.016
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Background and aims: To find new diagnostic markers to monitor isoniazid-induced liver injury. Methods: SD rats were treated with low dosage of isoniazid and the light microscopic findings of livers were collected. The methylation status of cytochrome p450 2E1 promoter was determined. Results: Cell edema and spotty necrosis on liver cells appeared in the experimental group and promoter methylation of cytochrome p450 2E1 was detected. Conclusions: Low-dosage isoniazid can induce liver injury. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：149 / 151
页数：3
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