Preliminary specificity study of the Bestel-Clement-Sorine electromechanical model of the heart using parameter calibration from medical images

被引：28

作者：

Marchesseau, S. ^{[1
]}

Delingette, H. ^{[1
]}

Sermesant, M. ^{[1
]}

Sorine, M. ^{[2
]}

Rhode, K. ^{[3
]}

Duckett, S. G. ^{[3
]}

Rinaldi, C. A. ^{[3
]}

Razavi, R. ^{[3
]}

Ayache, N. ^{[1
]}

机构：

[1] INRIA, Asclepios Res Project, Sophia Antipolis, France

[2] INRIA, Sisyphe Res Project, Rocquencourt, France

[3] Kings Coll London, St Thomas Hosp, Div Imaging Sci & Biomed Engn, London WC2R 2LS, England

来源：

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS | 2013年 / 20卷

基金：

英国工程与自然科学研究理事会;

关键词：

Computer model; Cardiac mechanics; Specificity analysis; Parameter calibration; FRAMEWORK; PREDICTION; TISSUE;

D O I：

10.1016/j.jmbbm.2012.11.021

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Patient-specific cardiac modelling can help in understanding pathophysiology and predict therapy effects. This requires the personalization of the geometry, kinematics, electrophysiology and mechanics. We use the Bestel-Clement-Sorine (BCS) electromechanical model of the heart, which provides reasonable accuracy with a reduced parameter number compared to the available clinical data at the organ level. We propose a preliminary specificity study to determine the relevant global parameters able to differentiate the pathological cases from the healthy controls. To this end, a calibration algorithm on global measurements is developed. This calibration method was tested successfully on 6 volunteers and 2 heart failure cases and enabled to tune up to 7 out of the 14 necessary parameters of the BCS model, from the volume and pressure curves. This specificity study confirmed domain-knowledge that the relaxation rate is impaired in post-myocardial infarction heart failure and the myocardial stiffness is increased in dilated cardiomyopathy heart failures. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：259 / 271

页数：13

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