Development of Biologically Active Compounds from Edible Plant Sources XXII. Triterpenoids from the Aerial Parts of Sajabalssuk (Artemisia princeps PAMPANINI)

被引:0
作者
Bang, Myun-Ho [3 ]
Cho, Jin-Gyeong [1 ,2 ]
Song, Myoung-Chong [1 ,2 ]
Lee, Dae-Young [1 ,2 ]
Han, Min-Woo [1 ,2 ]
Chung, Hae-Gon [4 ]
Jeong, Tae-Sook [5 ]
Lee, Kyung-Tae [6 ]
Choi, Myung-Sook [7 ]
Baek, Nam-In [1 ,2 ]
机构
[1] Grad Sch Biotechnol, Suwon 446701, South Korea
[2] Plant Metab Res Ctr, Suwon 446701, South Korea
[3] Skin Biotechnol Ctr, Suwon 443270, South Korea
[4] Ganghwa Agr R&D Ctr, Inchon 417833, South Korea
[5] Korea Res Inst Biosci & Biotechnol, Natl Res Lab Lipid Metab & Atherosclerosis, Taejon 305333, South Korea
[6] Kyung Hee Univ, Coll Pharm, Dept Biochem, Seoul 130701, South Korea
[7] Kyungpook Natl Univ, Dept Food Sci & Nutr, Taegu 702701, South Korea
来源
JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY | 2008年 / 51卷 / 03期
关键词
Acyl-CoA:Cholesterol acyltransferase (ACAT); Artemisia princeps PAMPANINI Sajabalssuk; wrightial; wrightial acetate; 27-norcycloart-20(21)-ene-25-al-3 beta-ol acetate; ursolic acid;
D O I
暂无
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
The aerial parts of Sajabalssuk (Artemisia princeps PAMPANINI, Sajabalssuk) was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and H2O, successively. From the EtOAc fraction, three cycloartane-type triterpnoids and one ursane-type triterpenoid were isolated through the repeated silica gel, ODS and Sephadex LH-20 column chromatographies. From the results of physico-chemical data including NMR, MS and IR, the chemical structures of the triterpenoids were determined as wrightial (1), wrightial acetate (2), 27-norcycloart-20(21)-ene-25-al-3 beta-ol acetate (3) and ursolic acid (4). No report has been found for isolation of compound 3 in the literature so far, and compounds 1, 2 and 3 were the first to be isolated from Sajabalssuk (Artemisia princeps PAMPANINI, Sajabalssuk). Also, compound I showed Acyl-CoA: Cholesterol acyltransferase (hACAT-1) and hACAT-2 inhibitory activity with the IC50 values of 33.0 and 45.0 mu g/ml, respectively. Compounds 2 and 3 inhibited hACAT-1 activity with the IC50 values of 12.0 and 16.0 mu g/ml, respectively.
引用
收藏
页码:223 / 227
页数:5
相关论文
共 26 条
[1]   Regulation of the phosphatidylinositol 3-Kinase-Akt and the mitogen-activated protein kinase pathways by ursolic acid in human endometrial cancer cells [J].
Achiwa, Yumiko ;
Hasegawa, Kiyoshi ;
Udagawa, Yasuhiro .
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2007, 71 (01) :31-37
[2]   TRITERPENOIDS FROM MANGIFERA-INDICA [J].
ANJANEYULU, V ;
PRASAD, KH ;
RAVI, K ;
CONNOLLY, JD .
PHYTOCHEMISTRY, 1985, 24 (10) :2359-2367
[3]   Cycloartane derivatives from Tillandsia usneoides [J].
Cabrera, GM ;
Gallo, M ;
Seldes, AM .
JOURNAL OF NATURAL PRODUCTS, 1996, 59 (04) :343-347
[4]   Cytotoxic activity of Origanum dictamnus [J].
Chinou, Ioanna ;
Liolios, Christos ;
Moreau, Dimitri ;
Roussakis, Christos .
FITOTERAPIA, 2007, 78 (05) :342-344
[5]  
CHO BB, 2004, KOREAN J FOOD NUTR, V17, P86
[6]  
Cho YH., 2001, KOR J INT AGR, V13, P313
[7]  
Ferreira MJU, 2001, NAT PROD LETT, V15, P363
[8]   Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-κB and Notch1 signaling [J].
Gao, Xiaohua ;
Deeb, Dorrah ;
Jiang, Hao ;
Liu, Yongbo ;
Dulchavsky, Scott A. ;
Gautam, Subhash C. .
JOURNAL OF NEURO-ONCOLOGY, 2007, 84 (02) :147-157
[9]   Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRIE) [J].
Horiuchi, Kumiko ;
Shiota, Sumiko ;
Hatano, Tsutomu ;
Yoshida, Takashi ;
Kuroda, Teruo ;
Tsuchiya, Tomofusa .
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2007, 30 (06) :1147-1149
[10]  
방면호, 2006, Applied Biological Chemistry, V49, P140