Development of Biologically Active Compounds from Edible Plant Sources XXII. Triterpenoids from the Aerial Parts of Sajabalssuk (Artemisia princeps PAMPANINI)

被引：0

作者：

Bang, Myun-Ho ^{[3
]}

Cho, Jin-Gyeong ^{[1
,2
]}

Song, Myoung-Chong ^{[1
,2
]}

Lee, Dae-Young ^{[1
,2
]}

Han, Min-Woo ^{[1
,2
]}

Chung, Hae-Gon ^{[4
]}

Jeong, Tae-Sook ^{[5
]}

Lee, Kyung-Tae ^{[6
]}

Choi, Myung-Sook ^{[7
]}

Baek, Nam-In ^{[1
,2
]}

机构：

[1] Grad Sch Biotechnol, Suwon 446701, South Korea

[2] Plant Metab Res Ctr, Suwon 446701, South Korea

[3] Skin Biotechnol Ctr, Suwon 443270, South Korea

[4] Ganghwa Agr R&D Ctr, Inchon 417833, South Korea

[5] Korea Res Inst Biosci & Biotechnol, Natl Res Lab Lipid Metab & Atherosclerosis, Taejon 305333, South Korea

[6] Kyung Hee Univ, Coll Pharm, Dept Biochem, Seoul 130701, South Korea

[7] Kyungpook Natl Univ, Dept Food Sci & Nutr, Taegu 702701, South Korea

来源：

JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY | 2008年 / 51卷 / 03期

关键词：

Acyl-CoA:Cholesterol acyltransferase (ACAT); Artemisia princeps PAMPANINI Sajabalssuk; wrightial; wrightial acetate; 27-norcycloart-20(21)-ene-25-al-3 beta-ol acetate; ursolic acid;

D O I：

暂无

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The aerial parts of Sajabalssuk (Artemisia princeps PAMPANINI, Sajabalssuk) was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and H2O, successively. From the EtOAc fraction, three cycloartane-type triterpnoids and one ursane-type triterpenoid were isolated through the repeated silica gel, ODS and Sephadex LH-20 column chromatographies. From the results of physico-chemical data including NMR, MS and IR, the chemical structures of the triterpenoids were determined as wrightial (1), wrightial acetate (2), 27-norcycloart-20(21)-ene-25-al-3 beta-ol acetate (3) and ursolic acid (4). No report has been found for isolation of compound 3 in the literature so far, and compounds 1, 2 and 3 were the first to be isolated from Sajabalssuk (Artemisia princeps PAMPANINI, Sajabalssuk). Also, compound I showed Acyl-CoA: Cholesterol acyltransferase (hACAT-1) and hACAT-2 inhibitory activity with the IC50 values of 33.0 and 45.0 mu g/ml, respectively. Compounds 2 and 3 inhibited hACAT-1 activity with the IC50 values of 12.0 and 16.0 mu g/ml, respectively.

引用

页码：223 / 227

页数：5

共 26 条

[1] Regulation of the phosphatidylinositol 3-Kinase-Akt and the mitogen-activated protein kinase pathways by ursolic acid in human endometrial cancer cells [J].