The Reelin Signaling Pathway Promotes Dendritic Spine Development in Hippocampal Neurons

被引:211
作者
Niu, Sanyong [2 ,3 ]
Yabut, Odessa [1 ,4 ]
D'Arcangelo, Gabriella [1 ]
机构
[1] Rutgers State Univ, Dept Cell Biol & Neurosci, Piscataway, NJ 08854 USA
[2] Texas Childrens Hosp, Cain Fdn Labs, Houston, TX 77030 USA
[3] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA
[4] Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA
关键词
Dab1; VLDLR; ApoER2; synapse; postsynaptic;
D O I
10.1523/JNEUROSCI.1917-08.2008
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The development of distinct cellular layers and precise synaptic circuits is essential for the formation of well functioning cortical structures in the mammalian brain. The extracellular protein Reelin, through the activation of a core signaling pathway, including the receptors ApoER2 and VLDLR (very low density lipoprotein receptor) and the adapter protein Dab1 (Disabled-1), controls the positioning of radially migrating principal neurons, promotes the extension of dendritic processes in immature forebrain neurons, and affects synaptic transmission. Here we report for the first time that the Reelin signaling pathway promotes the development of postsynaptic structures such as dendritic spines in hippocampal pyramidal neurons. Our data underscore the importance of Reelin as a factor that promotes the maturation of target neuronal populations and the development of excitatory circuits in the postnatal hippocampus. These findings may have implications for understanding the origin of cognitive disorders associated with Reelin deficiency.
引用
收藏
页码:10339 / 10348
页数:10
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