Targeting Pericyte Differentiation as a Strategy to Modulate Kidney Fibrosis in Diabetic Nephropathy

被引：37

作者：

Humphreys, Benjamin D. ^{[1
,2
,3
]}

机构：

[1] Brigham & Womens Hosp, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Harvard Stem Cell Inst, Cambridge, MA USA

来源：

SEMINARS IN NEPHROLOGY | 2012年 / 32卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Pericyte; myofibroblast; fibrosis; interstitium; diabetic nephropathy; TISSUE GROWTH-FACTOR; TO-MESENCHYMAL TRANSITION; UNILATERAL URETERAL OBSTRUCTION; HEDGEHOG PATHWAY ACTIVATION; TUBULAR EPITHELIAL-CELLS; HUMAN RENAL FIBROBLASTS; TRANSFORMING GROWTH-FACTOR-BETA-1; FACTOR-BETA; EXPERIMENTAL GLOMERULONEPHRITIS; MICROVASCULAR PERICYTES;

D O I：

10.1016/j.semnephrol.2012.07.009

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Pericytes are a heterogeneous group of extensively branched cells located in microvessels where they make focal contacts with endothelium. Pericytes stabilize blood vessels, regulate vascular tone, synthesize matrix, participate in repair, and serve as progenitor cells, among other functions. Recent work has highlighted the role of pericytes and pericyte-like cells in fibrosis, in which chronic injury triggers pericyte proliferation and differentiation into collagen-secretory, contractile myofibroblasts with migration away from vessels, causing microvascular rarefaction. In this review the developmental origins of kidney pericytes and perivascular fibroblasts are summarized, pericyte to myofibroblast transition in type I diabetic nephropathy is discussed, and the regulation of pericyte differentiation into myofibroblasts as a therapeutic target for treatment of diabetic nephropathy is described.© 2012 Elsevier Inc.

引用

页码：463 / 470

页数：8

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