Simultaneous determination of artemether and lumefantrine in fixed dose combination tablets by HPLC with UV detection

被引：41

作者：

Cesar, Isabela da Costa ^{[1
]}

Andrade Nogueira, Fernando Henrique ^{[1
]}

Pianetti, Gerson Antonio ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Fac Farm, Dept Prod Farmaceut, BR-31270901 Belo Horizonte, MG, Brazil

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2008年 / 48卷 / 03期

关键词：

Artemether; Lumefantrine; Antimalarials; HPLC-UV; Fixed dose combination tablets;

D O I：

10.1016/j.jpba.2008.05.022

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This paper describes the development and validation of a HPLC-UV method (210 nm) for the simultaneous quantitation of artemether and lumefantrine in fixed dose combination tablets. The method showed to be linear (r(2) > 0.99), precise (R.S.D. < 2.0%), accurate (recovery of 101.07% for artemether and 101.58% for lumefantrine), specific and robust. Four batches of artemether-lumefantrine tablets were assayed by the validated method. The artemether contents in the tablets varied from 98.61% to 103.35%, while lumefantrine contents were 97.92-100.48%. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：951 / 954

页数：4

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